This proposal is to continue the long-term support which has been the major financial basis of the work on total synthesis and methodology which has been the main focus of our research at Columbia for many years. Our main goal has been to develop synthetic methods to achieve desired transformations in a way that would also control the regio- and stereochemistry of the process. Eventually, of course, these methods are applied to the total synthesis of biologically interesting molecules. Over the years the specific targets have covered many structural types, such as steroids, indole alkaloids, prostaglandins, etc. At present, and not surprisingly, a major effort is toward the stereocontrolled total synthesis of the anticancer taxol. We hope, naturally, that our contributions will extend, beyond whatever specific target, to long- lasting advances in synthetic methodology of some generality.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM005147-41
Application #
2684608
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1985-09-01
Project End
2000-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
41
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Chemistry
Type
Other Domestic Higher Education
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027