The objective of this study is to use the laboratory mouse as a cytogenetic tool in four areas of mammalian cytogenetics: 1. the extent of linkage homology among mammals; 2. the mode of inheritance of chromosomal abnormalities; 3. the mechanism of X-inactivation; and 4. the relationship of gene dosage and gene product.
| Correa, Stephanie M; Washburn, Linda L; Kahlon, Ravi S et al. (2012) Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway. PLoS Genet 8:e1002569 |
| Bouma, Gerrit J; Hudson, Quanah J; Washburn, Linda L et al. (2010) New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation. Biol Reprod 82:380-9 |
| Wilhelm, Dagmar; Washburn, Linda L; Truong, Vy et al. (2009) Antagonism of the testis- and ovary-determining pathways during ovotestis development in mice. Mech Dev 126:324-36 |
| Bergstrom, David E; Bergstrom, Rebecca A; Munroe, Robert J et al. (2003) Overlapping deletions spanning the proximal two-thirds of the mouse t complex. Mamm Genome 14:817-29 |
