Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM024178-18A2
Application #
2174211
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1977-08-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Arizona
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Michalowski, Christine B; Little, John W (2013) Role of cis-acting sites in stimulation of the phage ? P(RM) promoter by CI-mediated looping. J Bacteriol 195:3401-11
Little, John W; Michalowski, Christine B (2010) Stability and instability in the lysogenic state of phage lambda. J Bacteriol 192:6064-76
Little, John W (2010) Evolution of complex gene regulatory circuits by addition of refinements. Curr Biol 20:R724-34
Degnan, Patrick H; Michalowski, Christine B; Babic, Andrea C et al. (2007) Conservation and diversity in the immunity regions of wild phages with the immunity specificity of phage lambda. Mol Microbiol 64:232-44
Babic, Andrea C; Little, John W (2007) Cooperative DNA binding by CI repressor is dispensable in a phage lambda variant. Proc Natl Acad Sci U S A 104:17741-6
Atsumi, Shota; Little, John W (2006) A synthetic phage lambda regulatory circuit. Proc Natl Acad Sci U S A 103:19045-50
Atsumi, Shota; Little, John W (2006) Role of the lytic repressor in prophage induction of phage lambda as analyzed by a module-replacement approach. Proc Natl Acad Sci U S A 103:4558-63
Michalowski, Christine B; Little, John W (2005) Positive autoregulation of cI is a dispensable feature of the phage lambda gene regulatory circuitry. J Bacteriol 187:6430-42
Atsumi, Shota; Little, John W (2004) Regulatory circuit design and evolution using phage lambda. Genes Dev 18:2086-94
Michalowski, Christine B; Short, Megan D; Little, John W (2004) Sequence tolerance of the phage lambda PRM promoter: implications for evolution of gene regulatory circuitry. J Bacteriol 186:7988-99

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