Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM024979-19
Application #
2174366
Study Section
AIDS and Related Research Study Section 4 (ARRD)
Project Start
1978-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Beadle, J R; Kini, G D; Aldern, K A et al. (1998) Alkylthioglycerol prodrugs of foscarnet: synthesis, oral bioavailability and structure-activity studies in human cytomegalovirus-, herpes simplex virus type 1- and human immunodeficiency virus type 1-infected cells. Antivir Chem Chemother 9:33-40
Hostetler, K Y; Beadle, J R; Kini, G D et al. (1997) Enhanced oral absorption and antiviral activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and related compounds in hepatitis B virus infection, in vitro. Biochem Pharmacol 53:1815-22
Taskintuna, I; Banker, A S; Flores-Aguilar, M et al. (1997) Evaluation of a novel lipid prodrug for intraocular drug delivery: effect of acyclovir diphosphate dimyristoylglycerol in a rabbit model with herpes simplex virus-1 retinitis. Retina 17:57-64
Kini, G D; Beadle, J R; Xie, H et al. (1997) Alkoxy propane prodrugs of foscarnet: effect of alkyl chain length on in vitro antiviral activity in cells infected with HIV-1, HSV-1 and HCMV. Antiviral Res 36:43-53
Schlame, M; Hostetler, K Y (1997) Cardiolipin synthase from mammalian mitochondria. Biochim Biophys Acta 1348:207-13
Kini, G D; Hostetler, S E; Beadle, J R et al. (1997) Synthesis and antiviral activity of 1-O-octadecyl-2-O-alkyl-sn-glycero-3-foscarnet conjugates in human cytomegalovirus-infected cells. Antiviral Res 36:115-24
Korba, B A; Xie, H; Wright, K N et al. (1996) Liver-targeted antiviral nucleosides: enhanced antiviral activity of phosphatidyl-dideoxyguanosine versus dideoxyguanosine in woodchuck hepatitis virus infection in vivo. Hepatology 23:958-63
Xie, H; Voronkov, M; Liotta, D C et al. (1995) Phosphatidyl-2',3'-dideoxy-3'-thiacytidine: synthesis and antiviral activity in hepatitis B-and HIV-1-infected cells. Antiviral Res 28:113-20
Shakiba, S; Freeman, W R; Flores-Aguilar, M et al. (1995) Antiviral effect in human cytomegalovirus-infected cells, pharmacokinetics, and intravitreal toxicology in rabbits of acyclovir diphosphate dimyristoylglycerol. Antimicrob Agents Chemother 39:1383-5
Hostetler, K Y; Richman, D D; Sridhar, C N et al. (1994) Phosphatidylazidothymidine and phosphatidyl-ddC: assessment of uptake in mouse lymphoid tissues and antiviral activities in human immunodeficiency virus-infected cells and in Rauscher leukemia virus-infected mice. Antimicrob Agents Chemother 38:2792-7

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