Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM025280-31
Application #
6689625
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Program Officer
Lograsso, Philip
Project Start
1978-07-01
Project End
2006-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
31
Fiscal Year
2004
Total Cost
$325,200
Indirect Cost

  Institution

Name
University of Toledo
Department
Biochemistry
Type
Schools of Medicine
DUNS #
807418939
City
Toledo
State
OH
Country
United States
Zip Code
43614

  Publications

Busnelli, Marta; Kleinau, Gunnar; Muttenthaler, Markus et al. (2016) Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure. J Med Chem 59:7152-66
Manning, M; Misicka, A; Olma, A et al. (2012) Oxytocin and vasopressin agonists and antagonists as research tools and potential therapeutics. J Neuroendocrinol 24:609-28
Busnelli, Marta; Saulière, Aude; Manning, Maurice et al. (2012) Functional selective oxytocin-derived agonists discriminate between individual G protein family subtypes. J Biol Chem 287:3617-29
Corbani, Maithe; Trueba, Miguel; Stoev, Stoytcho et al. (2011) Design, synthesis, and pharmacological characterization of fluorescent peptides for imaging human V1b vasopressin or oxytocin receptors. J Med Chem 54:2864-77
Albizu, Laura; Cottet, Martin; Kralikova, Michaela et al. (2010) Time-resolved FRET between GPCR ligands reveals oligomers in native tissues. Nat Chem Biol 6:587-94
Mouillac, B; Manning, M; Durroux, T (2008) Fluorescent agonists and antagonists for vasopressin/oxytocin G protein-coupled receptors: usefulness in ligand screening assays and receptor studies. Mini Rev Med Chem 8:996-1005
Chini, Bice; Manning, Maurice; Guillon, Gilles (2008) Affinity and efficacy of selective agonists and antagonists for vasopressin and oxytocin receptors: an ""easy guide"" to receptor pharmacology. Prog Brain Res 170:513-7
Manning, Maurice; Stoev, Stoytcho; Chini, Bice et al. (2008) Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents. Prog Brain Res 170:473-512
Manning, Maurice (2008) Impact of the Merrifield solid phase method on the design and synthesis of selective agonists and antagonists of oxytocin and vasopressin: a historical perspective. Biopolymers 90:203-12
Chini, B; Manning, M (2007) Agonist selectivity in the oxytocin/vasopressin receptor family: new insights and challenges. Biochem Soc Trans 35:737-41

Showing the most recent 10 out of 67 publications