Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM025521-17
Application #
2174480
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1979-04-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
17
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Utah
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Blank, Patrick N; Pemberton, Travis A; Chow, Jeng-Yeong et al. (2018) Crystal Structure of Cucumene Synthase, a Terpenoid Cyclase That Generates a Linear Triquinane Sesquiterpene. Biochemistry 57:6326-6335
Janczak, Matthew Walter; Poulter, C Dale (2016) Kinetic and Binding Studies of Streptococcus pneumoniae Type 2 Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase. Biochemistry 55:2260-8
Neti, Syam Sundar; Eckert, Debra M; Poulter, C Dale (2016) Construction of Functional Monomeric Type 2 Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase. Biochemistry 55:4229-38
Pan, Jian-Jung; Ramamoorthy, Gurusankar; Poulter, C Dale (2016) Absolute Configuration of Hydroxysqualene. An Intermediate in Bacterial Hopanoid Biosynthesis. Org Lett 18:512-5
Ramamoorthy, Gurusankar; Phan, Richard M; Poulter, C Dale (2016) Synthesis and Enzymatic Studies of Isoprenoid Thiolo Bisubstrate Analogues. J Org Chem 81:5093-100
Pan, Jian-Jung; Solbiati, Jose O; Ramamoorthy, Gurusankar et al. (2015) Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes. ACS Cent Sci 1:77-82
Chow, Jeng-Yeong; Tian, Bo-Xue; Ramamoorthy, Gurusankar et al. (2015) Computational-guided discovery and characterization of a sesquiterpene synthase from Streptomyces clavuligerus. Proc Natl Acad Sci U S A 112:5661-6
Ramamoorthy, Gurusankar; Pugh, Mark L; Tian, Bo-Xue et al. (2015) Synthesis and enzymatic studies of bisubstrate analogues for farnesyl diphosphate synthase. J Org Chem 80:3902-13
Faus, Isabelle; Reinhard, Annegret; Rackwitz, Sergej et al. (2015) Isoprenoid Biosynthesis in Pathogenic Bacteria: Nuclear Resonance Vibrational Spectroscopy Provides Insight into the Unusual [4Fe-4S] Cluster of the E.?coli LytB/IspH Protein. Angew Chem Int Ed Engl 54:12584-7
de Ruyck, Jerome; Janczak, Matthew W; Neti, Syam Sundar et al. (2014) Determination of kinetics and the crystal structure of a novel type 2 isopentenyl diphosphate: dimethylallyl diphosphate isomerase from Streptococcus pneumoniae. Chembiochem 15:1452-8

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