Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM025698-29
Application #
2174522
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1978-06-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
29
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Oregon
Department
Type
Organized Research Units
DUNS #
948117312
City
Eugene
State
OR
Country
United States
Zip Code
97403

  Publications

Birrell, G Bruce; Zaikova, Tatiana O; Rukavishnikov, Aleksey V et al. (2003) Allosteric interactions within subsites of a monomeric enzyme: kinetics of fluorogenic substrates of PI-specific phospholipase C. Biophys J 84:3264-75
Ryan, M; Liu, T; Dahlquist, F W et al. (2001) A catalytic diad involved in substrate-assisted catalysis: NMR study of hydrogen bonding and dynamics at the active site of phosphatidylinositol-specific phospholipase C. Biochemistry 40:9743-50
Zaikova, T O; Rukavishnikov, A V; Birrell, G B et al. (2001) Synthesis of fluorogenic substrates for continuous assay of phosphatidylinositol-specific phospholipase C. Bioconjug Chem 12:307-13
Hedberg, K K; Stauff, C; Hoyer-Hansen, G et al. (2000) High-molecular-weight serum protein complexes differentially promote cell migration and the focal adhesion localization of the urokinase receptor in human glioma cells. Exp Cell Res 257:67-81
Griffith, O H; Ryan, M (1999) Bacterial phosphatidylinositol-specific phospholipase C: structure, function, and interaction with lipids. Biochim Biophys Acta 1441:237-54
Rukavishnikov, A V; Zaikova, T O; Birrell, G B et al. (1999) Synthesis of a new fluorogenic substrate for the continuous assay of mammalian phosphoinositide-specific phospholipase C. Bioorg Med Chem Lett 9:1133-6
Menco, B P; Birrell, G B; Fuller, C M et al. (1998) Ultrastructural localization of amiloride-sensitive sodium channels and Na+,K(+)-ATPase in the rat's olfactory epithelial surface. Chem Senses 23:137-49
Liu, T; Ryan, M; Dahlquist, F W et al. (1997) Determination of pKa values of the histidine side chains of phosphatidylinositol-specific phospholipase C from Bacillus cereus by NMR spectroscopy and site-directed mutagenesis. Protein Sci 6:1937-44
Gassler, C S; Ryan, M; Liu, T et al. (1997) Probing the roles of active site residues in phosphatidylinositol-specific phospholipase C from Bacillus cereus by site-directed mutagenesis. Biochemistry 36:12802-13
Birrell, G B; Hedberg, K K; Barklis, E et al. (1997) Partial isolation from intact cells of a cell surface-exposed lysophosphatidylinositol-phospholipase C. J Cell Biochem 65:550-64

Showing the most recent 10 out of 40 publications