Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM026237-18
Application #
2174667
Study Section
Biochemistry Study Section (BIO)
Project Start
1979-04-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Boston College
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
045896339
City
Chestnut Hill
State
MA
Country
United States
Zip Code
02467
Cockrell, Gregory M; Kantrowitz, Evan R (2013) ViewMotions Rainbow: a new method to illustrate molecular motions in proteins. J Mol Graph Model 40:48-53
Cockrell, Gregory M; Zheng, Yunan; Guo, Wenyue et al. (2013) New paradigm for allosteric regulation of Escherichia coli aspartate transcarbamoylase. Biochemistry 52:8036-47
Peterson, Alexis W; Cockrell, Gregory M; Kantrowitz, Evan R (2012) A second allosteric site in Escherichia coli aspartate transcarbamoylase. Biochemistry 51:4776-8
Lipscomb, William N; Kantrowitz, Evan R (2012) Structure and mechanisms of Escherichia coli aspartate transcarbamoylase. Acc Chem Res 45:444-53
Guo, Wenyue; West, Jay M; Dutton, Andrew S et al. (2012) Trapping and structure determination of an intermediate in the allosteric transition of aspartate transcarbamoylase. Proc Natl Acad Sci U S A 109:7741-6
Kantrowitz, Evan R (2012) Allostery and cooperativity in Escherichia coli aspartate transcarbamoylase. Arch Biochem Biophys 519:81-90
Cockrell, Gregory M; Kantrowitz, Evan R (2012) Metal ion involvement in the allosteric mechanism of Escherichia coli aspartate transcarbamoylase. Biochemistry 51:7128-37
Harris, Katharine M; Cockrell, Gregory M; Puleo, David E et al. (2011) Crystallographic snapshots of the complete catalytic cycle of the unregulated aspartate transcarbamoylase from Bacillus subtilis. J Mol Biol 411:190-200
Heng, Sabrina; Harris, Katharine M; Kantrowitz, Evan R (2010) Designing inhibitors against fructose 1,6-bisphosphatase: exploring natural products for novel inhibitor scaffolds. Eur J Med Chem 45:1478-84
Mendes, Kimberly R; Martinez, Jessica A; Kantrowitz, Evan R (2010) Asymmetric allosteric signaling in aspartate transcarbamoylase. ACS Chem Biol 5:499-506

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