Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM026351-18
Application #
2174696
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1979-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Connecticut
Department
Biochemistry
Type
Schools of Dentistry
DUNS #
City
Farmington
State
CT
Country
United States
Zip Code
06030
Heinemann, F Scott; Korza, George; Ozols, Juris (2003) A plasminogen-like protein selectively degrades stearoyl-CoA desaturase in liver microsomes. J Biol Chem 278:42966-75
Heinemann, F Scott; Mziaut, Hassan; Korza, George et al. (2003) A microsomal endopeptidase from liver that preferentially degrades stearoyl-CoA desaturase. Biochemistry 42:6929-37
Mziaut, Hassan; Korza, George; Benraiss, Abdellatif et al. (2002) Selective mutagenesis of lysyl residues leads to a stable and active form of delta 9 stearoyl-CoA desaturase. Biochim Biophys Acta 1583:45-52
Mziaut, H; Korza, G; Elkahloun, A G et al. (2001) Induction of stearoyl CoA desaturase is associated with high-level induction of emerin RNA. Biochem Biophys Res Commun 282:910-5
Mziaut, H; Korza, G; Ozols, J (2000) The N terminus of microsomal delta 9 stearoyl-CoA desaturase contains the sequence determinant for its rapid degradation. Proc Natl Acad Sci U S A 97:8883-8
Ozols, J (1999) Isolation and complete covalent structure of liver microsomal paraoxonase. Biochem J 338 ( Pt 2):265-72
Mziaut, H; Korza, G; Hand, A R et al. (1999) Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase. J Biol Chem 274:14122-9
Ozols, J (1998) Determination of lumenal orientation of microsomal 50-kDa esterase/N-deacetylase. Biochemistry 37:10336-44
Kumar, V; Heinemann, F S; Ozols, J (1998) Interleukin-2 induces N-glycosylation in T-cells: characterization of human lymphocyte oligosaccharyltransferase. Biochem Biophys Res Commun 247:524-9
Heinemann, F S; Ozols, J (1998) Degradation of stearoyl-coenzyme A desaturase: endoproteolytic cleavage by an integral membrane protease. Mol Biol Cell 9:3445-53

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