Abstract

The overall objective of this work is elucidation of the structural and functional basis for the replication and transfer of bacterial plasmids. The project involves investigations designed to gain insight into the molecular mechanism and gene products that regulate these fundamental biological processes of plasmids.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM026355-10
Application #
3273850
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1979-07-01
Project End
1990-03-31
Budget Start
1988-07-01
Budget End
1990-03-31
Support Year
10
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Miller, Christine; Ingmer, Hanne; Thomsen, Line Elnif et al. (2003) DpiA binding to the replication origin of Escherichia coli plasmids and chromosomes destabilizes plasmid inheritance and induces the bacterial SOS response. J Bacteriol 185:6025-31
Xu, Feng-Feng; Gaggero, Carina; Cohen, Stanley N (2002) Polyadenylation can regulate ColE1 type plasmid copy number independently of any effect on RNAI decay by decreasing the interaction of antisense RNAI with its RNAII target. Plasmid 48:49-58
Ingmer, H; Miller, C; Cohen, S N (2001) The RepA protein of plasmid pSC101 controls Escherichia coli cell division through the SOS response. Mol Microbiol 42:519-26
Miller, C; Cohen, S N (1999) Separate roles of Escherichia coli replication proteins in synthesis and partitioning of pSC101 plasmid DNA. J Bacteriol 181:7552-7
Ten Hagen, K G; Ravnan, J B; Cohen, S N (1995) Disparate replication properties of integrated and extrachromosomal forms of bovine papilloma virus in ID13 cells. J Mol Biol 254:119-29
Conley, D L; Cohen, S N (1995) Isolation and characterization of plasmid mutations that enable partitioning of pSC101 replicons lacking the partition (par) locus. J Bacteriol 177:1086-9
Conley, D L; Cohen, S N (1995) Effects of the pSC101 partition (par) locus on in vivo DNA supercoiling near the plasmid replication origin. Nucleic Acids Res 23:701-7
Ravnan, J B; Cohen, S N (1995) Transformed mouse cell lines that consist predominantly of cells maintaining bovine papilloma virus at high copy number. Virology 213:526-34
Ten Hagen, K G; Cohen, S N (1993) Timing of replication of beta satellite repeats of human chromosomes. Nucleic Acids Res 21:2139-42
Miller, C A; Cohen, S N (1993) The partition (par) locus of pSC101 is an enhancer of plasmid incompatibility. Mol Microbiol 9:695-702

Showing the most recent 10 out of 24 publications