Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM026643-18
Application #
2174748
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1979-07-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Delaware
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716
Hudson, Devin A; Caplan, Jeffrey L; Thorpe, Colin (2018) Designing Flavoprotein-GFP Fusion Probes for Analyte-Specific Ratiometric Fluorescence Imaging. Biochemistry 57:1178-1189
Yu, Tiantian; Laird, Joanna R; Prescher, Jennifer A et al. (2018) Gaussia princeps luciferase: a bioluminescent substrate for oxidative protein folding. Protein Sci 27:1509-1517
Fass, Deborah; Thorpe, Colin (2018) Chemistry and Enzymology of Disulfide Cross-Linking in Proteins. Chem Rev 118:1169-1198
Foster, Celia K; Thorpe, Colin (2017) Challenges in the evaluation of thiol-reactive inhibitors of human protein disulfide Isomerase. Free Radic Biol Med 108:741-749
Zhang, Han; Trout, William S; Liu, Shuang et al. (2016) Rapid Bioorthogonal Chemistry Turn-on through Enzymatic or Long Wavelength Photocatalytic Activation of Tetrazine Ligation. J Am Chem Soc 138:5978-83
Hudson, Devin A; Thorpe, Colin (2015) Mia40 is a facile oxidant of unfolded reduced proteins but shows minimal isomerase activity. Arch Biochem Biophys 579:1-7
Sapra, Aparna; Ramadan, Danny; Thorpe, Colin (2015) Multivalency in the inhibition of oxidative protein folding by arsenic(III) species. Biochemistry 54:612-21
Hudson, Devin A; Gannon, Shawn A; Thorpe, Colin (2015) Oxidative protein folding: from thiol-disulfide exchange reactions to the redox poise of the endoplasmic reticulum. Free Radic Biol Med 80:171-82
Israel, Benjamin A; Jiang, Lingxi; Gannon, Shawn A et al. (2014) Disulfide bond generation in mammalian blood serum: detection and purification of quiescin-sulfhydryl oxidase. Free Radic Biol Med 69:129-35
Schaefer-Ramadan, Stephanie; Thorpe, Colin; Rozovsky, Sharon (2014) Site-specific insertion of selenium into the redox-active disulfide of the flavoprotein augmenter of liver regeneration. Arch Biochem Biophys 548:60-5

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