Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM027673-16
Application #
2174974
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1980-04-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Medical University of South Carolina
Department
Physiology
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Atkinson, Sarah J; Nolan, Meghan; Klingbeil, Lindsey et al. (2016) Intestine-Derived Matrix Metalloproteinase-8 Is a Critical Mediator of Polymicrobial Peritonitis. Crit Care Med 44:e200-6
Botez, Gabriela; Piraino, Giovanna; Hake, Paul W et al. (2015) Age-dependent therapeutic effects of liver X receptor-? activation in murine polymicrobial sepsis. Innate Immun 21:609-18
Guan, Shuwen; Guo, Changrun; Zingarelli, Basilia et al. (2014) Combined treatment with a CXCL12 analogue and antibiotics improves survival and neutrophil recruitment and function in murine sepsis. Immunology :
Fan, Hongkuan; Goodwin, Andrew J; Chang, Eugene et al. (2014) Endothelial progenitor cells and a stromal cell-derived factor-1? analogue synergistically improve survival in sepsis. Am J Respir Crit Care Med 189:1509-19
Fan, Hongkuan (2014) ?-Arrestins 1 and 2 are critical regulators of inflammation. Innate Immun 20:451-60
Fan, Hongkuan; Wong, Donald; Ashton, Sarah H et al. (2012) Beneficial effect of a CXCR4 agonist in murine models of systemic inflammation. Inflammation 35:130-7
Li, Pengfei; Neubig, Richard R; Zingarelli, Basilia et al. (2012) Toll-like receptor-induced inflammatory cytokines are suppressed by gain of function or overexpression of G?(i2) protein. Inflammation 35:1611-7
Fan, Hongkuan; Li, Pengfei; Zingarelli, Basilia et al. (2011) Heterotrimeric G?(i) proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis. Biochim Biophys Acta 1813:466-72
Li, Pengfei; Cook, James A; Gilkeson, Gary S et al. (2011) Increased expression of beta-arrestin 1 and 2 in murine models of rheumatoid arthritis: isoform specific regulation of inflammation. Mol Immunol 49:64-74
Fan, Hongkuan; Bitto, Alessandra; Zingarelli, Basilia et al. (2010) Beta-arrestin 2 negatively regulates sepsis-induced inflammation. Immunology 130:344-51

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