Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM027906-17
Application #
2175033
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1980-04-01
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
17
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Biochemistry
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Martin, Peter D; James, Zachary M; Thomas, David D (2018) Effect of Phosphorylation on Interactions between Transmembrane Domains of SERCA and Phospholamban. Biophys J 114:2573-2583
Stroik, Daniel R; Yuen, Samantha L; Janicek, Kevyn A et al. (2018) Targeting protein-protein interactions for therapeutic discovery via FRET-based high-throughput screening in living cells. Sci Rep 8:12560
Nelson, Sarah E D; Ha, Kim N; Gopinath, Tata et al. (2018) Effects of the Arg9Cys and Arg25Cys mutations on phospholamban's conformational equilibrium in membrane bilayers. Biochim Biophys Acta Biomembr 1860:1335-1341
Schaaf, Tory M; Peterson, Kurt C; Grant, Benjamin D et al. (2017) Spectral Unmixing Plate Reader: High-Throughput, High-Precision FRET Assays in Living Cells. SLAS Discov 22:250-261
Schaaf, Tory M; Peterson, Kurt C; Grant, Benjamin D et al. (2017) High-Throughput Spectral and Lifetime-Based FRET Screening in Living Cells to Identify Small-Molecule Effectors of SERCA. SLAS Discov 22:262-273
Rebbeck, Robyn T; Nitu, Florentin R; Rohde, David et al. (2016) S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine ReceptorĀ·Calmodulin Complex. J Biol Chem 291:15896-907
Autry, Joseph M; Thomas, David D; Espinoza-Fonseca, L Michel (2016) Sarcolipin Promotes Uncoupling of the SERCA Ca2+ Pump by Inducing a Structural Rearrangement in the Energy-Transduction Domain. Biochemistry 55:6083-6086
McCaffrey, Jesse E; James, Zachary M; Svensson, Bengt et al. (2016) A bifunctional spin label reports the structural topology of phospholamban in magnetically-aligned bicelles. J Magn Reson 262:50-56
Svensson, Bengt; Autry, Joseph M; Thomas, David D (2016) Molecular Modeling of Fluorescent SERCA Biosensors. Methods Mol Biol 1377:503-22
Ablorh, Naa-Adjeley D; Thomas, David D (2015) Phospholamban phosphorylation, mutation, and structural dynamics: a biophysical approach to understanding and treating cardiomyopathy. Biophys Rev 7:63-76

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