Abstract

Six areas of theoretical population genetic research are to be developed. Studies of linkage and fertility selection, including the properties of genetic modifiers of recombination will be continued. Models of mixed inbreeding and outcrossing, appropriate to plant population genetics, will be constructed. The interaction of the mating system with epistatic selection and population subdivision will be elucidated for one and two gene systems. Exact analysis of the question of optimal mutation rates is our third area of research. The fourth concerns whether the even sex ratio, previously shown to be genetically optimal when sex is controlled by a single gene, is optimal with more complex sex determination. Our studies of cultural transmission and evolution will include both evolutionary modelling and data analysis of traits of mixed genetic and cultural etiology. Finally we continue our exact genetic modelling of kin selection with two linked loci and in subdivided populations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM028016-08
Application #
3275267
Study Section
Genetics Study Section (GEN)
Project Start
1980-07-01
Project End
1988-06-30
Budget Start
1987-07-01
Budget End
1988-06-30
Support Year
8
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
Schools of Arts and Sciences
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Pinho, Ricardo; Garcia, Victor; Feldman, Marcus W (2014) Phenotype accessibility and noise in random threshold gene regulatory networks. PLoS One 10:e0119972
Domschke, Pia; Trucu, Dumitru; Gerisch, Alf et al. (2014) Mathematical modelling of cancer invasion: implications of cell adhesion variability for tumour infiltrative growth patterns. J Theor Biol 361:41-60
Aoki, Kenichi; Feldman, Marcus W (2014) Evolution of learning strategies in temporally and spatially variable environments: a review of theory. Theor Popul Biol 91:3-19
Greenspoon, Philip B; M'Gonigle, Leithen K (2014) Host-parasite interactions and the evolution of nonrandom mating. Evolution 68:3570-80
Greenspoon, Philip B; M'Gonigle, Leithen K (2013) The evolution of mutation rate in an antagonistic coevolutionary model with maternal transmission of parasites. Proc Biol Sci 280:20130647
Palmer, Michael E; Moudgil, Arnav; Feldman, Marcus W (2013) Long-term evolution is surprisingly predictable in lattice proteins. J R Soc Interface 10:20130026
Greenspoon, Philip B; M'Gonigle, Leithen K (2013) Can positive frequency dependence facilitate plant coexistence? Trends Ecol Evol 28:317-8
Song, Z; Feldman, M W (2013) The coevolution of long-term pair bonds and cooperation. J Evol Biol 26:963-70
Palmer, M E; Lipsitch, M; Moxon, E R et al. (2013) Broad conditions favor the evolution of phase-variable loci. MBio 4:e00430-12
Creanza, Nicole; Fogarty, Laurel; Feldman, Marcus W (2012) Models of cultural niche construction with selection and assortative mating. PLoS One 7:e42744

Showing the most recent 10 out of 231 publications