Abstract

Two areas of theoretical population genetic research are proposed. The first concerns a number of aspects of multilocus population genetics. Among these are the elucidation of the properties of genetic modifiers of recombination in large and small populations and under a variety of natural selection regimes. The population consequences of fitness differences between genotypes in cis and trans configurations will be investigated. A new representation of general recombination schemes will be applied to the study of covariances between relatives of a quantitative character. The second area concerns traits whose transmission is both genetic and cultural. The consequences of different selection regimes and transmission patterns for the distribution of such traits within populations will be studied. Covariances between relatives will be computed in cases where transmission is influenced by interacting genes. The effect of an important culturally transmitted trait, infanticide against one sex, on the primary sex ratio in a population will be studied.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM028016-15
Application #
2175072
Study Section
Genetics Study Section (GEN)
Project Start
1980-07-01
Project End
1997-06-30
Budget Start
1994-07-01
Budget End
1995-06-30
Support Year
15
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Pinho, Ricardo; Garcia, Victor; Feldman, Marcus W (2014) Phenotype accessibility and noise in random threshold gene regulatory networks. PLoS One 10:e0119972
Domschke, Pia; Trucu, Dumitru; Gerisch, Alf et al. (2014) Mathematical modelling of cancer invasion: implications of cell adhesion variability for tumour infiltrative growth patterns. J Theor Biol 361:41-60
Aoki, Kenichi; Feldman, Marcus W (2014) Evolution of learning strategies in temporally and spatially variable environments: a review of theory. Theor Popul Biol 91:3-19
Greenspoon, Philip B; M'Gonigle, Leithen K (2014) Host-parasite interactions and the evolution of nonrandom mating. Evolution 68:3570-80
Greenspoon, Philip B; M'Gonigle, Leithen K (2013) The evolution of mutation rate in an antagonistic coevolutionary model with maternal transmission of parasites. Proc Biol Sci 280:20130647
Palmer, Michael E; Moudgil, Arnav; Feldman, Marcus W (2013) Long-term evolution is surprisingly predictable in lattice proteins. J R Soc Interface 10:20130026
Greenspoon, Philip B; M'Gonigle, Leithen K (2013) Can positive frequency dependence facilitate plant coexistence? Trends Ecol Evol 28:317-8
Song, Z; Feldman, M W (2013) The coevolution of long-term pair bonds and cooperation. J Evol Biol 26:963-70
Palmer, M E; Lipsitch, M; Moxon, E R et al. (2013) Broad conditions favor the evolution of phase-variable loci. MBio 4:e00430-12
Palmer, Michael E; Feldman, Marcus W (2012) Survivability is more fundamental than evolvability. PLoS One 7:e38025

Showing the most recent 10 out of 231 publications