Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM029006-15
Application #
2175361
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1981-04-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Duke University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Chen, Yu-Tsung Shane; Wu, Jianhong; Modrich, Paul et al. (2016) The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation. J Biol Chem 291:13216-28
Chen, Stefanie Hartman; Plank, Jody L; Willcox, Smaranda et al. (2014) Top3? is required during the convergent migration step of double Holliday junction dissolution. PLoS One 9:e83582
Lee, Shun-Hsiao; Siaw, Grace Ee-Lu; Willcox, Smaranda et al. (2013) Synthesis and dissolution of hemicatenanes by type IA DNA topoisomerases. Proc Natl Acad Sci U S A 110:E3587-94
Chen, Stefanie Hartman; Plank, Jody L; Willcox, Smaranda et al. (2013) Improved methods for creating migratable Holliday junction substrates. Nucleic Acids Res 41:e60
Chen, Yu-Tsung; Collins, Tammy R L; Guan, Ziqiang et al. (2012) Probing conformational changes in human DNA topoisomerase II? by pulsed alkylation mass spectrometry. J Biol Chem 287:25660-8
Capp, Christopher; Qian, Yushen; Sage, Harvey et al. (2010) Separate and combined biochemical activities of the subunits of a naturally split reverse gyrase. J Biol Chem 285:39637-45
Wu, Jianhong; Feng, Liping; Hsieh, Tao-shih (2010) Drosophila topo IIIalpha is required for the maintenance of mitochondrial genome and male germ-line stem cells. Proc Natl Acad Sci U S A 107:6228-33
Wu, Jianhong; Phatnani, Hemali P; Hsieh, Tao-Shih et al. (2010) The phosphoCTD-interacting domain of Topoisomerase I. Biochem Biophys Res Commun 397:117-9
Capp, Christopher; Wu, Jianhong; Hsieh, Tao-Shih (2010) RecQ4: the second replicative helicase? Crit Rev Biochem Mol Biol 45:233-42
Collins, Tammy R L; Hsieh, Tao-Shih (2009) Monitoring the topoisomerase II DNA gate conformational change with fluorescence resonance energy transfer. Methods Mol Biol 582:59-70

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