Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM029433-14
Application #
2175506
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1982-07-01
Project End
1997-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Emory University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Edmondson, Dale E (2014) Hydrogen peroxide produced by mitochondrial monoamine oxidase catalysis: biological implications. Curr Pharm Des 20:155-60
Martinoli, Christian; Dudek, Hanna M; Orru, Roberto et al. (2013) Beyond the Protein Matrix: Probing Cofactor Variants in a Baeyer-Villiger Oxygenation Reaction. ACS Catal 3:3058-3062
Orru, R; Aldeco, M; Edmondson, D E (2013) Do MAO A and MAO B utilize the same mechanism for the C-H bond cleavage step in catalysis? Evidence suggesting differing mechanisms. J Neural Transm (Vienna) 120:847-51
Binda, Claudia; Aldeco, Milagros; Mattevi, Andrea et al. (2011) Interactions of monoamine oxidases with the antiepileptic drug zonisamide: specificity of inhibition and structure of the human monoamine oxidase B complex. J Med Chem 54:909-12
Wang, Jin; Edmondson, Dale E (2011) ²H kinetic isotope effects and pH dependence of catalysis as mechanistic probes of rat monoamine oxidase A: comparisons with the human enzyme. Biochemistry 50:7710-7
Aldeco, Milagros; Arslan, Betul Kacar; Edmondson, Dale E (2011) Catalytic and inhibitor binding properties of zebrafish monoamine oxidase (zMAO): comparisons with human MAO A and MAO B. Comp Biochem Physiol B Biochem Mol Biol 159:78-83
Milczek, Erika M; Binda, Claudia; Rovida, Stefano et al. (2011) The 'gating' residues Ile199 and Tyr326 in human monoamine oxidase B function in substrate and inhibitor recognition. FEBS J 278:4860-9
Wang, Jin; Edmondson, Dale E (2011) Topological probes of monoamine oxidases A and B in rat liver mitochondria: inhibition by TEMPO-substituted pargyline analogues and inactivation by proteolysis. Biochemistry 50:2499-505
Binda, Claudia; Mattevi, Andrea; Edmondson, Dale E (2011) Structural properties of human monoamine oxidases A and B. Int Rev Neurobiol 100:1-11
Binda, Claudia; Aldeco, Milagros; Geldenhuys, Werner J et al. (2011) Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs. ACS Med Chem Lett 3:39-42

Showing the most recent 10 out of 87 publications