Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM030228-12
Application #
2175730
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1981-07-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Colorado at Boulder
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
Boulder
State
CO
Country
United States
Zip Code
80309
Ball, Kerri A; Nelson, Andrew W; Foster, Daniel G et al. (2012) Nitric oxide produced by cytochrome c oxidase helps stabilize HIF-1ýý in hypoxic mammalian cells. Biochem Biophys Res Commun 420:727-32
Poyton, Robert O; Ball, Kerri A (2011) Therapeutic photobiomodulation: nitric oxide and a novel function of mitochondrial cytochrome c oxidase. Discov Med 11:154-9
Li, Bin; Skinner, Craig; Castello, Pablo R et al. (2011) Identification of potential calorie restriction-mimicking yeast mutants with increased mitochondrial respiratory chain and nitric oxide levels. J Aging Res 2011:673185
Poyton, Robert O; Ball, Kerri A; Castello, Pablo R (2009) Mitochondrial generation of free radicals and hypoxic signaling. Trends Endocrinol Metab 20:332-40
Poyton, Robert O; Castello, Pablo R; Ball, Kerri A et al. (2009) Mitochondria and hypoxic signaling: a new view. Ann N Y Acad Sci 1177:48-56
Woo, Dong Kyun; Poyton, Robert O (2009) The absence of a mitochondrial genome in rho0 yeast cells extends lifespan independently of retrograde regulation. Exp Gerontol 44:390-7
Woo, Dong Kyun; Phang, Tzu L; Trawick, John D et al. (2009) Multiple pathways of mitochondrial-nuclear communication in yeast: intergenomic signaling involves ABF1 and affects a different set of genes than retrograde regulation. Biochim Biophys Acta 1789:135-45
Castello, Pablo R; Woo, Dong Kyun; Ball, Kerri et al. (2008) Oxygen-regulated isoforms of cytochrome c oxidase have differential effects on its nitric oxide production and on hypoxic signaling. Proc Natl Acad Sci U S A 105:8203-8
Castello, Pablo R; David, Pamela S; McClure, Travis et al. (2006) Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: implications for oxygen sensing and hypoxic signaling in eukaryotes. Cell Metab 3:277-87
David, Pamela S; Poyton, Robert O (2005) Effects of a transition from normoxia to anoxia on yeast cytochrome c oxidase and the mitochondrial respiratory chain: implications for hypoxic gene induction. Biochim Biophys Acta 1709:169-80

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