Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM030736-14
Application #
2175892
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1983-02-01
Project End
1997-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Biochemistry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Sinha, Prem Kumar; Nakamaru-Ogiso, Eiko; Torres-Bacete, Jesus et al. (2012) Electron transfer in subunit NuoI (TYKY) of Escherichia coli NADH:quinone oxidoreductase (NDH-1). J Biol Chem 287:17363-73
Ohnishi, Tomoko; Nakamaru-Ogiso, Eiko; Ohnishi, S Tsuyoshi (2010) A new hypothesis on the simultaneous direct and indirect proton pump mechanisms in NADH-quinone oxidoreductase (complex I). FEBS Lett 584:4131-7
Nakamaru-Ogiso, Eiko; Kao, Mou-Chieh; Chen, Han et al. (2010) The membrane subunit NuoL(ND5) is involved in the indirect proton pumping mechanism of Escherichia coli complex I. J Biol Chem 285:39070-8
Ohnishi, S Tsuyoshi; Ohnishi, Tomoko (2010) An adder-mixer for adding a few microliters of reagent into an electron paramagnetic resonance quartz tube. Anal Biochem 406:89-90
Ohnishi, S Tsuyoshi; Salerno, John C; Ohnishi, Tomoko (2010) Possible roles of two quinone molecules in direct and indirect proton pumps of bovine heart NADH-quinone oxidoreductase (complex I). Biochim Biophys Acta 1797:1891-3
Nakamaru-Ogiso, Eiko; Han, Hongna; Matsuno-Yagi, Akemi et al. (2010) The ND2 subunit is labeled by a photoaffinity analogue of asimicin, a potent complex I inhibitor. FEBS Lett 584:883-8
Ohnishi, S Tsuyoshi; Shinzawa-Itoh, Kyoko; Ohta, Kazuhiro et al. (2010) New insights into the superoxide generation sites in bovine heart NADH-ubiquinone oxidoreductase (Complex I): the significance of protein-associated ubiquinone and the dynamic shifting of generation sites between semiflavin and semiquinone radicals. Biochim Biophys Acta 1797:1901-9
Fato, Romana; Bergamini, Christian; Bortolus, Marco et al. (2009) Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species. Biochim Biophys Acta 1787:384-92
Zhang, Yan; Lyver, Elise R; Nakamaru-Ogiso, Eiko et al. (2008) Dre2, a conserved eukaryotic Fe/S cluster protein, functions in cytosolic Fe/S protein biogenesis. Mol Cell Biol 28:5569-82
Ohnishi, Tomoko; Nakamaru-Ogiso, Eiko (2008) Were there any ""misassignments"" among iron-sulfur clusters N4, N5 and N6b in NADH-quinone oxidoreductase (complex I)? Biochim Biophys Acta 1777:703-10

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