Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM030859-22
Application #
6687320
Study Section
Medicinal Chemistry Study Section (MCHA)
Program Officer
Schwab, John M
Project Start
1982-08-01
Project End
2006-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
22
Fiscal Year
2004
Total Cost
$366,499
Indirect Cost

  Institution

Name
University of California Irvine
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Büschleb, Martin; Dorich, Stéphane; Hanessian, Stephen et al. (2016) Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms. Angew Chem Int Ed Engl 55:4156-86
Canham, Stephen M; Hafensteiner, Benjamin D; Lebsack, Alec D et al. (2015) Stereocontrolled enantioselective total synthesis of the [2+2] quadrigemine alkaloids. Tetrahedron 71:6424-6436
Baumann, Marcus; Dieskau, André P; Loertscher, Brad M et al. (2015) Tricyclic Analogues of Epidithiodioxopiperazine Alkaloids with Promising In Vitro and In Vivo Antitumor Activity. Chem Sci 6:4451-4457
Quasdorf, Kyle W; Overman, Larry E (2014) Catalytic enantioselective synthesis of quaternary carbon stereocentres. Nature 516:181-91
Jabri, Salman Y; Overman, Larry E (2013) Enantioselective total syntheses of plectosphaeroic acids B and C. J Org Chem 78:8766-88
DeLorbe, John E; Horne, David; Jove, Richard et al. (2013) General approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors: enantioselective total syntheses of (+)- and (-)-gliocladine C, (+)-leptosin D, (+)-T988C, (+)-bionectin A, and (+)-gliocladin A. J Am Chem Soc 135:4117-28
Jabri, Salman Y; Overman, Larry E (2013) Enantioselective total synthesis of plectosphaeroic acid B. J Am Chem Soc 135:4231-4
Cannon, Jeffrey S; Frederich, James H; Overman, Larry E (2012) Palladacyclic imidazoline-naphthalene complexes: synthesis and catalytic performance in Pd(II)-catalyzed enantioselective reactions of allylic trichloroacetimidates. J Org Chem 77:1939-51
Cannon, Jeffrey S; Overman, Larry E (2012) Is there no end to the total syntheses of strychnine? Lessons learned in strategy and tactics in total synthesis. Angew Chem Int Ed Engl 51:4288-311
DeLorbe, John E; Jabri, Salman Y; Mennen, Steven M et al. (2011) Enantioselective total synthesis of (+)-gliocladine C: convergent construction of cyclotryptamine-fused polyoxopiperazines and a general approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors. J Am Chem Soc 133:6549-52

Showing the most recent 10 out of 30 publications