Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM030910-15
Application #
2175948
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1982-07-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Biochemistry
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Goodman, Michael C; Xu, Shu; Rouzer, Carol A et al. (2018) Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site. J Biol Chem 293:3028-3038
Sanders, Charles R; Hutchison, James M (2018) Membrane properties that shape the evolution of membrane enzymes. Curr Opin Struct Biol 51:80-91
Peng, Hui; Zhang, Yixiang; Palmer, Lauren D et al. (2017) Hydrogen Sulfide and Reactive Sulfur Species Impact Proteome S-Sulfhydration and Global Virulence Regulation in Staphylococcus aureus. ACS Infect Dis 3:744-755
Droege, Kristin D; Keithly, Mary E; Sanders, Charles R et al. (2017) Structural Dynamics of 15-Lipoxygenase-2 via Hydrogen-Deuterium Exchange. Biochemistry 56:5065-5074
Spahiu, Linda; Ă…lander, Johan; Ottosson-Wadlund, Astrid et al. (2017) Global Kinetic Mechanism of Microsomal Glutathione Transferase 1 and Insights into Dynamic Enzyme Activation. Biochemistry 56:3089-3098
Whitson, Jeremy A; Sell, David R; Goodman, Michael C et al. (2016) Evidence of Dual Mechanisms of Glutathione Uptake in the Rodent Lens: A Novel Role for Vitreous Humor in Lens Glutathione Homeostasis. Invest Ophthalmol Vis Sci 57:3914-25
Raouf, Joan; Rafique, Nazmi; Goodman, Michael Christopher et al. (2016) Arg126 and Asp49 Are Essential for the Catalytic Function of Microsomal Prostaglandin E2 Synthase 1 and Ser127 Is Not. PLoS One 11:e0163600
Winchell, Kelsey R; Egeler, Paul W; VanDuinen, Andrew J et al. (2016) A Structural, Functional, and Computational Analysis of BshA, the First Enzyme in the Bacillithiol Biosynthesis Pathway. Biochemistry 55:4654-65
VanDuinen, Andrew J; Winchell, Kelsey R; Keithly, Mary E et al. (2015) X-ray crystallographic structure of BshC, a unique enzyme involved in bacillithiol biosynthesis. Biochemistry 54:100-3
Shen, Jiangchuan; Keithly, Mary E; Armstrong, Richard N et al. (2015) Staphylococcus aureus CstB Is a Novel Multidomain Persulfide Dioxygenase-Sulfurtransferase Involved in Hydrogen Sulfide Detoxification. Biochemistry 54:4542-54

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