Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM031073-06S1
Application #
3278963
Study Section
Molecular Biology Study Section (MBY)
Project Start
1982-07-01
Project End
1990-06-30
Budget Start
1987-07-01
Budget End
1988-06-30
Support Year
6
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Ast, G; Pavelitz, T; Weiner, A M (2001) Sequences upstream of the branch site are required to form helix II between U2 and U6 snRNA in a trans-splicing reaction. Nucleic Acids Res 29:1741-9
Yu, A; Fan, H Y; Liao, D et al. (2000) Activation of p53 or loss of the Cockayne syndrome group B repair protein causes metaphase fragility of human U1, U2, and 5S genes. Mol Cell 5:801-10
Liao, D; Yu, A; Weiner, A M (1999) Coexpression of the adenovirus 12 E1B 55 kDa oncoprotein and cellular tumor suppressor p53 is sufficient to induce metaphase fragility of the human RNU2 locus. Virology 254:11-23
Frey, M R; Bailey, A D; Weiner, A M et al. (1999) Association of snRNA genes with coiled bodies is mediated by nascent snRNA transcripts. Curr Biol 9:126-35
Li, Z; Bailey, A D; Buchowski, J et al. (1998) A tandem array of minimal U1 small nuclear RNA genes is sufficient to generate a new adenovirus type 12-inducible chromosome fragile site. J Virol 72:4205-11
Yu, A; Bailey, A D; Weiner, A M (1998) Metaphase fragility of the human RNU1 and RNU2 loci is induced by actinomycin D through a p53-dependent pathway. Hum Mol Genet 7:609-17
Liao, D; Pavelitz, T; Weiner, A M (1998) Characterization of a novel class of interspersed LTR elements in primate genomes: structure, genomic distribution, and evolution. J Mol Evol 46:649-60
Bailey, A D; Pavelitz, T; Weiner, A M (1998) The microsatellite sequence (CT)n x (GA)n promotes stable chromosomal integration of large tandem arrays of functional human U2 small nuclear RNA genes. Mol Cell Biol 18:2262-71
Li, Z; Yu, A; Weiner, A M (1998) Adenovirus type 12-induced fragility of the human RNU2 locus requires p53 function. J Virol 72:4183-91
Ast, G; Weiner, A M (1997) Antisense oligonucleotide binding to U5 snRNP induces a conformational change that exposes the conserved loop of U5 snRNA. Nucleic Acids Res 25:3508-13

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