The basic objectives of this proposal are to develop new reagents for organic synthesis which provide new approaches to natural product and drug synthesis. Reagents will be derived from titanium-methylene and ketene chemistry that is uder development in our laboratory. These reagents provide new pathways for the construction of carbon-carbon double bonds, the quaternarization of ketone-carbon centers and new paths to metallacene mediated aldol chemistry.
Showing the most recent 10 out of 69 publications