Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM031382-13
Application #
2176111
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1984-04-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Fruen, Bradley R; Balog, Edward M; Schafer, Janet et al. (2005) Direct detection of calmodulin tuning by ryanodine receptor channel targets using a Ca2+-sensitive acrylodan-labeled calmodulin. Biochemistry 44:278-84
Fruen, Bradley R; Black, D J; Bloomquist, Rachel A et al. (2003) Regulation of the RYR1 and RYR2 Ca2+ release channel isoforms by Ca2+-insensitive mutants of calmodulin. Biochemistry 42:2740-7
Balog, Edward M; Norton, Laura E; Bloomquist, Rachel A et al. (2003) Calmodulin oxidation and methionine to glutamine substitutions reveal methionine residues critical for functional interaction with ryanodine receptor-1. J Biol Chem 278:15615-21
Louis, C F; Balog, E M; Fruen, B R (2001) Malignant hyperthermia: an inherited disorder of skeletal muscle Ca+ regulation. Biosci Rep 21:155-68
Balog, E M; Fruen, B R; Shomer, N H et al. (2001) Divergent effects of the malignant hyperthermia-susceptible Arg(615)-->Cys mutation on the Ca(2+) and Mg(2+) dependence of the RyR1. Biophys J 81:2050-8
Zhao, F; Li, P; Chen, S R et al. (2001) Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity. J Biol Chem 276:13810-6
Balog, E M; Fruen, B R; Kane, P K et al. (2000) Mechanisms of P(i) regulation of the skeletal muscle SR Ca(2+) release channel. Am J Physiol Cell Physiol 278:C601-11
Palnitkar, S S; Mickelson, J R; Louis, C F et al. (1997) Pharmacological distinction between dantrolene and ryanodine binding sites: evidence from normal and malignant hyperthermia-susceptible porcine skeletal muscle. Biochem J 326 ( Pt 3):847-52
Fruen, B R; Mickelson, J R; Louis, C F (1997) Dantrolene inhibition of sarcoplasmic reticulum Ca2+ release by direct and specific action at skeletal muscle ryanodine receptors. J Biol Chem 272:26965-71
Fruen, B R; Kane, P K; Mickelson, J R et al. (1996) Chloride-dependent sarcoplasmic reticulum Ca2+ release correlates with increased Ca2+ activation of ryanodine receptors. Biophys J 71:2522-30

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