Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM032191-15
Application #
2176471
Study Section
Biochemistry Study Section (BIO)
Project Start
1987-09-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Morar, Mariya; Hoskins, Aaron A; Stubbe, JoAnne et al. (2008) Formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima: structural insights into complex formation. Biochemistry 47:7816-30
Hoskins, Aaron A; Morar, Mariya; Kappock, T Joseph et al. (2007) N5-CAIR mutase: role of a CO2 binding site and substrate movement in catalysis. Biochemistry 46:2842-55
Anand, Ruchi; Hoskins, Aaron A; Stubbe, JoAnne et al. (2004) Domain organization of Salmonella typhimurium formylglycinamide ribonucleotide amidotransferase revealed by X-ray crystallography. Biochemistry 43:10328-42
Anand, Ruchi; Hoskins, Aaron A; Bennett, Eric M et al. (2004) A model for the Bacillus subtilis formylglycinamide ribonucleotide amidotransferase multiprotein complex. Biochemistry 43:10343-52
Hoskins, Aaron A; Anand, Ruchi; Ealick, Steven E et al. (2004) The formylglycinamide ribonucleotide amidotransferase complex from Bacillus subtilis: metabolite-mediated complex formation. Biochemistry 43:10314-27
Zilles, J L; Kappock, T J; Stubbe, J et al. (2001) Altered pathway routing in a class of Salmonella enterica serovar Typhimurium mutants defective in aminoimidazole ribonucleotide synthetase. J Bacteriol 183:2234-40
Kappock, T J; Ealick, S E; Stubbe, J (2000) Modular evolution of the purine biosynthetic pathway. Curr Opin Chem Biol 4:567-72
Mathews, I I; Kappock, T J; Stubbe, J et al. (1999) Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway. Structure 7:1395-406
Thoden, J B; Kappock, T J; Stubbe, J et al. (1999) Three-dimensional structure of N5-carboxyaminoimidazole ribonucleotide synthetase: a member of the ATP grasp protein superfamily. Biochemistry 38:15480-92
Li, C; Kappock, T J; Stubbe, J et al. (1999) X-ray crystal structure of aminoimidazole ribonucleotide synthetase (PurM), from the Escherichia coli purine biosynthetic pathway at 2.5 A resolution. Structure 7:1155-66

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