Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
7R01GM032485-07
Application #
3281366
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1988-12-01
Project End
1991-08-31
Budget Start
1988-12-01
Budget End
1989-08-31
Support Year
7
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
009214214
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Srikrishna, G; Wang, L; Freeze, H H (1998) Fucosebeta-1-P-Ser is a new type of glycosylation: using antibodies to identify a novel structure in Dictyostelium discoideum and study multiple types of fucosylation during growth and development. Glycobiology 8:799-811
Souza, G M; Mehta, D P; Lammertz, M et al. (1997) Dictyostelium lysosomal proteins with different sugar modifications sort to functionally distinct compartments. J Cell Sci 110 ( Pt 18):2239-48
Srikrishna, G; Varki, N M; Newell, P C et al. (1997) An IgG monoclonal antibody against Dictyostelium discoideum glycoproteins specifically recognizes Fucalpha1,6GlcNAcbeta in the core of N-linked glycans. Localized expression of core-fucosylated glycoconjugates in human tissues. J Biol Chem 272:25743-52
Freeze, H H; Lammertz, M; Iranfar, N et al. (1997) Consequences of disrupting the gene that encodes alpha-glucosidase II in the N-linked oligosaccharide biosynthesis pathway of Dictyostelium discoideum. Dev Genet 21:177-86
Chui, D; Oh-Eda, M; Liao, Y F et al. (1997) Alpha-mannosidase-II deficiency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis. Cell 90:157-67
Varki, A; Freeze, H H (1994) The major glycosylation pathways of mammalian membranes. A summary. Subcell Biochem 22:71-100
Freeze, H H; Bush, J M; Cardelli, J (1990) Biochemical and genetic analysis of an antigenic determinant found on N-linked oligosaccharides in Dictyostelium. Dev Genet 11:463-72
Freeze, H H; Koza-Taylor, P; Saunders, A et al. (1989) The effects of altered N-linked oligosaccharide structures on maturation and targeting of lysosomal enzymes in Dictyostelium discoideum. J Biol Chem 264:19278-86
Lacoste, C H; Freeze, H H; Jones, J A et al. (1989) Characteristics of the sulfation of N-linked oligosaccharides in vesicles from Dictyostelium discoideum: in vitro sulfation of lysosomal enzymes. Arch Biochem Biophys 273:505-15
Freeze, H H; Willies, L; Hamilton, S et al. (1989) Two mutants of Dictyostelium discoideum that lack a sulfated carbohydrate antigenic determinant synthesize a truncated lipid-linked precursor of N-linked oligosaccharides. J Biol Chem 264:5653-9

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