It is stated that the overall objectives of this research are to apply new methodology for the introduction of nitrogen functionality into organic molecules to the synthesis of the amaryllidaceae alkaloids pancratistatin, crinine and lycorine, aminoglycosides, aminonucleoside precursors, AZT variations, aminocyclitols, and the insecticidal alkaloid stemofoline. The principal investigator notes that all of the routes are short and make use of the alpha- and beta-azidonation chemistry and that all of the above compounds have interesting biological properties.
| Black, Phillip J; Hecker, Evan A; Magnus, Philip (2007) Studies towards the synthesis of the marine alkaloid chartelline C. Tetrahedron Lett 48:6364-6367 |
| Cheung, Chi-Ming; Goldberg, Frederick W; Magnus, Philip et al. (2007) An expedient formal total synthesis of (-)-diazonamide A via a powerful, stereoselective O-aryl to C-aryl migration to form the C10 quaternary center. J Am Chem Soc 129:12320-7 |
| Magnus, Philip; Matthews, Kenneth S; Lynch, Vince (2003) New strategy for the synthesis of tetrahydroisoquinoline alkaloids. Org Lett 5:2181-4 |
