Abstract

It is stated that the overall objectives of this research are to apply new methodology for the introduction of nitrogen functionality into organic molecules to the synthesis of the amaryllidaceae alkaloids pancratistatin, crinine and lycorine, aminoglycosides, aminonucleoside precursors, AZT variations, aminocyclitols, and the insecticidal alkaloid stemofoline. The principal investigator notes that all of the routes are short and make use of the alpha- and beta-azidonation chemistry and that all of the above compounds have interesting biological properties.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM032718-20
Application #
6519123
Study Section
Medicinal Chemistry Study Section (MCHA)
Program Officer
Schwab, John M
Project Start
1989-01-01
Project End
2003-11-30
Budget Start
2002-04-01
Budget End
2003-11-30
Support Year
20
Fiscal Year
2002
Total Cost
$263,409
Indirect Cost

  Institution

Name
University of Texas Austin
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Austin
State
TX
Country
United States
Zip Code
78712

  Publications

Cheung, Chi-Ming; Goldberg, Frederick W; Magnus, Philip et al. (2007) An expedient formal total synthesis of (-)-diazonamide A via a powerful, stereoselective O-aryl to C-aryl migration to form the C10 quaternary center. J Am Chem Soc 129:12320-7
Black, Phillip J; Hecker, Evan A; Magnus, Philip (2007) Studies towards the synthesis of the marine alkaloid chartelline C. Tetrahedron Lett 48:6364-6367
Magnus, Philip; Matthews, Kenneth S; Lynch, Vince (2003) New strategy for the synthesis of tetrahydroisoquinoline alkaloids. Org Lett 5:2181-4