Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM032734-12
Application #
2176721
Study Section
Biochemistry Study Section (BIO)
Project Start
1984-05-01
Project End
1997-06-30
Budget Start
1996-01-01
Budget End
1997-06-30
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Nallagatla, Subba Rao; Jones, Christie N; Ghosh, Saikat Kumar B et al. (2013) Native tertiary structure and nucleoside modifications suppress tRNA's intrinsic ability to activate the innate immune sensor PKR. PLoS One 8:e57905
Christian, Brooke E; Spremulli, Linda L (2012) Mechanism of protein biosynthesis in mammalian mitochondria. Biochim Biophys Acta 1819:1035-54
Bilbille, Yann; Gustilo, Estella M; Harris, Kimberly A et al. (2011) The human mitochondrial tRNAMet: structure/function relationship of a unique modification in the decoding of unconventional codons. J Mol Biol 406:257-74
Haque, Md Emdadul; Koc, Hasan; Cimen, Huseyin et al. (2011) Contacts between mammalian mitochondrial translational initiation factor 3 and ribosomal proteins in the small subunit. Biochim Biophys Acta 1814:1779-84
Christian, Brooke E; Haque, Md Emdadul; Spremulli, Linda L (2010) The effect of spermine on the initiation of mitochondrial protein synthesis. Biochem Biophys Res Commun 391:942-6
Akama, Kenta; Christian, Brooke E; Jones, Christie N et al. (2010) Analysis of the functional consequences of lethal mutations in mitochondrial translational elongation factors. Biochim Biophys Acta 1802:692-8
Haque, Md Emdadul; Elmore, Kevin B; Tripathy, Ashutosh et al. (2010) Properties of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L and its interactions with mammalian mitochondrial ribosomes. J Biol Chem 285:28353-62
Haque, Md Emdadul; Spremulli, Linda L; Fecko, Christopher J (2010) Identification of protein-protein and protein-ribosome interacting regions of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L. J Biol Chem 285:34991-8
Christian, Brooke E; Spremulli, Linda L (2010) Preferential selection of the 5'-terminal start codon on leaderless mRNAs by mammalian mitochondrial ribosomes. J Biol Chem 285:28379-86
Christian, Brooke E; Spremulli, Linda L (2009) Evidence for an active role of IF3mt in the initiation of translation in mammalian mitochondria. Biochemistry 48:3269-78

Showing the most recent 10 out of 70 publications