Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM033048-14
Application #
2176823
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1988-07-01
Project End
1999-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Worcester Foundation for Biomedical Research
Department
Type
DUNS #
City
Shrewsbury
State
MA
Country
United States
Zip Code
01545
Son, Kyonghee; Smith, Tara C; Luna, Elizabeth J (2015) Supervillin binds the Rac/Rho-GEF Trio and increases Trio-mediated Rac1 activation. Cytoskeleton (Hoboken) 72:47-64
Spinazzola, Janelle M; Smith, Tara C; Liu, Min et al. (2015) Gamma-sarcoglycan is required for the response of archvillin to mechanical stimulation in skeletal muscle. Hum Mol Genet 24:2470-81
Lawlor, Michael W; Viola, Marissa G; Meng, Hui et al. (2014) Differential muscle hypertrophy is associated with satellite cell numbers and Akt pathway activation following activin type IIB receptor inhibition in Mtm1 p.R69C mice. Am J Pathol 184:1831-42
Fang, Zhiyou; Luna, Elizabeth J (2013) Supervillin-mediated suppression of p53 protein enhances cell survival. J Biol Chem 288:7918-29
Fedechkin, Stanislav O; Brockerman, Jacob; Luna, Elizabeth J et al. (2013) An N-terminal, 830 residues intrinsically disordered region of the cytoskeleton-regulatory protein supervillin contains Myosin II- and F-actin-binding sites. J Biomol Struct Dyn 31:1150-9
Smith, Tara C; Fridy, Peter C; Li, Yinyin et al. (2013) Supervillin binding to myosin II and synergism with anillin are required for cytokinesis. Mol Biol Cell 24:3603-19
Edelstein, Leonard C; Luna, Elizabeth J; Gibson, Ian B et al. (2012) Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress. Circulation 125:2762-71
Bhuwania, Ridhirama; Cornfine, Susanne; Fang, Zhiyou et al. (2012) Supervillin couples myosin-dependent contractility to podosomes and enables their turnover. J Cell Sci 125:2300-14
Hao, Zhikui; Cai, Yujie; Liao, Xiangru et al. (2011) Chitinolyticbacter meiyuanensis SYBC-H1T, gen. nov., sp. nov., a chitin-degrading bacterium isolated from soil. Curr Microbiol 62:1732-8
Fang, Zhiyou; Takizawa, Norio; Wilson, Korey A et al. (2010) The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility. Traffic 11:782-99

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