Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM033192-03S1
Application #
3282595
Study Section
Biophysics and Biophysical Chemistry B Study Section (BBCB)
Project Start
1984-02-01
Project End
1987-04-30
Budget Start
1987-02-01
Budget End
1987-04-30
Support Year
3
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Wayne State University
Department
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Martin, P D; Malkowski, M G; DiMaio, J et al. (1996) Bovine thrombin complexed with an uncleavable analog of residues 7-19 of fibrinogen A alpha: geometry of the catalytic triad and interactions of the P1', P2', and P3' substrate residues. Biochemistry 35:13030-9
Martin, P D; Eisele, K L; Doyle, M A et al. (1996) Molecular symmetry of the dodecamer subunit of Lumbricus terrestris hemoglobin. J Mol Biol 255:170-5
Malkowski, M G; Wu, J Y; Lazar, J B et al. (1995) The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution. J Biol Chem 270:7077-87
de Mel, V S; Kamberov, E S; Martin, P D et al. (1994) Preliminary X-ray diffraction analysis of crystals of the PII protein from Escherichia coli. J Mol Biol 243:796-8
de Mel, V S; Doyle, M A; Gladysheva, T B et al. (1994) Crystallization and preliminary X-ray diffraction analysis of the ArsC protein from the Escherichia coli arsenical resistance plasmid, R773. J Mol Biol 242:701-2
Zdanov, A; Wu, S; DiMaio, J et al. (1993) Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6. Proteins 17:252-65
Vitali, J; Martin, P D; Malkowski, M G et al. (1992) The structure of a complex of bovine alpha-thrombin and recombinant hirudin at 2.8-A resolution. J Biol Chem 267:17670-8
Stuckey, J A; St Charles, R; Edwards, B F (1992) A model of the platelet factor 4 complex with heparin. Proteins 14:277-87
Martin, P D; Robertson, W; Turk, D et al. (1992) The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution. J Biol Chem 267:7911-20
Ni, F; Ripoll, D R; Martin, P D et al. (1992) Solution structure of a platelet receptor peptide bound to bovine alpha-thrombin. Biochemistry 31:11551-7

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