Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM033841-12
Application #
2177159
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1984-07-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1998-03-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Northern Illinois University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
De Kalb
State
IL
Country
United States
Zip Code
60115
Mitchell, J L; Rupert, J; Leyser, A et al. (1998) Mammalian cell polyamine homeostasis is altered by the radioprotector WR1065. Biochem J 335 ( Pt 2):329-34
Mitchell, J L; Judd, G G; Leyser, A et al. (1998) Osmotic stress induces variation in cellular levels of ornithine decarboxylase-antizyme. Biochem J 329 ( Pt 3):453-9
Mitchell, J L; Choe, C Y; Judd, G G (1996) Ornithine decarboxylase stability in HMOA and DH23b cells is not due to post-translational truncation of a C-terminal recognition site. Biochem J 318 ( Pt 3):879-82
Mitchell, J L; Choe, C Y; Judd, G G et al. (1996) Overproduction of stable ornithine decarboxylase and antizyme in the difluoromethylornithine-resistant cell line DH23b. Biochem J 317 ( Pt 3):811-6
Mitchell, J L; Choe, C Y; Judd, G G (1996) Feedback repression of ornithine decarboxylase synthesis mediated by antizyme. Biochem J 320 ( Pt 3):755-60
Mitchell, J L; Judd, G G; Bareyal-Leyser, A et al. (1994) Feedback repression of polyamine transport is mediated by antizyme in mammalian tissue-culture cells. Biochem J 299 ( Pt 1):19-22
Mitchell, J L; Diveley Jr, R R; Bareyal-Leyser, A (1992) Feedback repression of polyamine uptake into mammalian cells requires active protein synthesis. Biochem Biophys Res Commun 186:81-8
Mitchell, J L; Diveley Jr, R R; Bareyal-Leyser, A et al. (1992) Abnormal accumulation and toxicity of polyamines in a difluoromethylornithine-resistant HTC cell variant. Biochim Biophys Acta 1136:136-42
Mitchell, J L; Kurzeja, R J; Marsh, J F et al. (1992) Recovery of ornithine decarboxylase activity after inhibition with alpha-difluoromethylornithine. Biochem Biophys Res Commun 187:443-7
Mitchell, J L; Hoff, J A; Bareyal-Leyser, A (1991) Stable ornithine decarboxylase in a rat hepatoma cell line selected for resistance to alpha-difluoromethylornithine. Arch Biochem Biophys 290:143-52

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