Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
7R01GM034009-19
Application #
6920545
Study Section
Biochemistry Study Section (BIO)
Program Officer
Jones, Warren
Project Start
1984-07-01
Project End
2006-11-30
Budget Start
2004-07-16
Budget End
2004-11-30
Support Year
19
Fiscal Year
2004
Total Cost
$145,325
Indirect Cost

  Institution

Name
Louisiana State University Hsc New Orleans
Department
Biochemistry
Type
Schools of Medicine
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112

  Publications

Todaro, Dustin R; Augustus-Wallace, Allison C; Klein, Jennifer M et al. (2018) Oligomerization of the HECT ubiquitin ligase NEDD4-2/NEDD4L is essential for polyubiquitin chain assembly. J Biol Chem 293:18192-18206
Todaro, Dustin R; Augustus-Wallace, Allison C; Klein, Jennifer M et al. (2017) The mechanism of neural precursor cell expressed developmentally down-regulated 4-2 (Nedd4-2)/NEDD4L-catalyzed polyubiquitin chain assembly. J Biol Chem 292:19521-19536
Ronchi, Virginia P; Kim, Elizabeth D; Summa, Christopher M et al. (2017) In silico modeling of the cryptic E2?ubiquitin-binding site of E6-associated protein (E6AP)/UBE3A reveals the mechanism of polyubiquitin chain assembly. J Biol Chem 292:18006-18023
Edwards, Daniel J; Streich Jr, Frederick C; Ronchi, Virginia P et al. (2014) Convergent evolution in the assembly of polyubiquitin degradation signals by the Shigella flexneri IpaH9.8 ligase. J Biol Chem 289:34114-28
Ronchi, Virginia P; Klein, Jennifer M; Edwards, Daniel J et al. (2014) The active form of E6-associated protein (E6AP)/UBE3A ubiquitin ligase is an oligomer. J Biol Chem 289:1033-48
Streich Jr, Frederick C; Ronchi, Virginia P; Connick, J Patrick et al. (2013) Tripartite motif ligases catalyze polyubiquitin chain formation through a cooperative allosteric mechanism. J Biol Chem 288:8209-21
Ronchi, Virginia P; Klein, Jennifer M; Haas, Arthur L (2013) E6AP/UBE3A ubiquitin ligase harbors two E2~ubiquitin binding sites. J Biol Chem 288:10349-60
Ronchi, Virginia P; Haas, Arthur L (2012) Measuring rates of ubiquitin chain formation as a functional readout of ligase activity. Methods Mol Biol 832:197-218
Tokgöz, Zeynep; Siepmann, Thomas J; Streich Jr, Frederick et al. (2012) E1-E2 interactions in ubiquitin and Nedd8 ligation pathways. J Biol Chem 287:311-21
Kumar, Brajesh; Lecompte, Kimberly G; Klein, Jennifer M et al. (2010) Ser(120) of Ubc2/Rad6 regulates ubiquitin-dependent N-end rule targeting by E3{alpha}/Ubr1. J Biol Chem 285:41300-9

Showing the most recent 10 out of 57 publications