Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM034478-12
Application #
2177446
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1985-08-30
Project End
1997-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Tufts University
Department
Physiology
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02111
Collins, Michael P; Forgac, Michael (2018) Regulation of V-ATPase Assembly in Nutrient Sensing and Function of V-ATPases in Breast Cancer Metastasis. Front Physiol 9:902
McGuire, Christina M; Forgac, Michael (2018) Glucose starvation increases V-ATPase assembly and activity in mammalian cells through AMP kinase and phosphatidylinositide 3-kinase/Akt signaling. J Biol Chem 293:9113-9123
Cotter, Kristina; Liberman, Rachel; Sun-Wada, GeHong et al. (2016) The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer. Oncotarget 7:46142-46157
McGuire, Christina; Cotter, Kristina; Stransky, Laura et al. (2016) Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness. Biochim Biophys Acta 1857:1213-1218
Stransky, Laura A; Forgac, Michael (2015) Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly. J Biol Chem 290:27360-9
Cotter, Kristina; Stransky, Laura; McGuire, Christina et al. (2015) Recent Insights into the Structure, Regulation, and Function of the V-ATPases. Trends Biochem Sci 40:611-622
Cotter, Kristina; Capecci, Joseph; Sennoune, Souad et al. (2015) Activity of plasma membrane V-ATPases is critical for the invasion of MDA-MB231 breast cancer cells. J Biol Chem 290:3680-92
Liberman, Rachel; Bond, Sarah; Shainheit, Mara G et al. (2014) Regulated assembly of vacuolar ATPase is increased during cluster disruption-induced maturation of dendritic cells through a phosphatidylinositol 3-kinase/mTOR-dependent pathway. J Biol Chem 289:1355-63
Liberman, Rachel; Cotter, Kristina; Baleja, James D et al. (2013) Structural analysis of the N-terminal domain of subunit a of the yeast vacuolar ATPase (V-ATPase) using accessibility of single cysteine substitutions to chemical modification. J Biol Chem 288:22798-808
Capecci, Joseph; Forgac, Michael (2013) The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells. J Biol Chem 288:32731-41

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