Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM034504-12
Application #
2177464
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1984-12-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Serganov, Alexander; Patel, Dinshaw J (2012) Metabolite recognition principles and molecular mechanisms underlying riboswitch function. Annu Rev Biophys 41:343-70
Kuryavyi, Vitaly; Cahoon, Laty A; Seifert, H Steven et al. (2012) RecA-binding pilE G4 sequence essential for pilin antigenic variation forms monomeric and 5' end-stacked dimeric parallel G-quadruplexes. Structure 20:2090-102
Ren, Aiming; Rajashankar, Kanagalaghatta R; Patel, Dinshaw J (2012) Fluoride ion encapsulation by Mg2+ ions and phosphates in a fluoride riboswitch. Nature 486:85-9
Serganov, Alexander; Patel, Dinshaw J (2012) Molecular recognition and function of riboswitches. Curr Opin Struct Biol 22:279-86
Pikovskaya, Olga; Polonskaia, Anna; Patel, Dinshaw J et al. (2011) Structural principles of nucleoside selectivity in a 2'-deoxyguanosine riboswitch. Nat Chem Biol 7:748-55
Kuryavyi, Vitaly; Patel, Dinshaw J (2010) Solution structure of a unique G-quadruplex scaffold adopted by a guanosine-rich human intronic sequence. Structure 18:73-82
Pikovskaya, Olga; Serganov, Artem A; Polonskaia, Ann et al. (2009) Preparation and crystallization of riboswitch-ligand complexes. Methods Mol Biol 540:115-28
Serganov, Alexander; Patel, Dinshaw J (2009) Amino acid recognition and gene regulation by riboswitches. Biochim Biophys Acta 1789:592-611
Westhof, Eric; Patel, Dinshaw J (2009) Nucleic acids: how high resolution structural biology help us to understand Darwinian evolution. Curr Opin Struct Biol 19:235-8
Lim, Kah Wai; Amrane, Samir; Bouaziz, Serge et al. (2009) Structure of the human telomere in K+ solution: a stable basket-type G-quadruplex with only two G-tetrad layers. J Am Chem Soc 131:4301-9

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