Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM035498-04A4
Application #
2177925
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1988-02-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Xie, Yehua; Hu, Yongjun; Smith, David E (2016) The proton-coupled oligopeptide transporter 1 plays a major role in the intestinal permeability and absorption of 5-aminolevulinic acid. Br J Pharmacol 173:167-76
Xie, Yehua; Shen, Hong; Hu, Yongjun et al. (2016) Population pharmacokinetic modeling of cefadroxil renal transport in wild-type and Pept2 knockout mice. Xenobiotica 46:342-9
Hu, Yongjun; Xie, Yehua; Keep, Richard F et al. (2014) Divergent developmental expression and function of the proton-coupled oligopeptide transporters PepT2 and PhT1 in regional brain slices of mouse and rat. J Neurochem 129:955-65
Wang, Yuqing; Sun, Dongli; Song, Feifeng et al. (2014) Expression and regulation of the proton-coupled oligopeptide transporter PhT2 by LPS in macrophages and mouse spleen. Mol Pharm 11:1880-8
Hu, Yongjun; Xie, Yehua; Wang, Yuqing et al. (2014) Development and characterization of a novel mouse line humanized for the intestinal peptide transporter PEPT1. Mol Pharm 11:3737-46
Yang, Bei; Hu, Yongjun; Smith, David E (2013) Impact of peptide transporter 1 on the intestinal absorption and pharmacokinetics of valacyclovir after oral dose escalation in wild-type and PepT1 knockout mice. Drug Metab Dispos 41:1867-74
Huh, Yeamin; Keep, Richard F; Smith, David E (2013) Impact of lipopolysaccharide-induced inflammation on the disposition of the aminocephalosporin cefadroxil. Antimicrob Agents Chemother 57:6171-8
Posada, Maria M; Smith, David E (2013) Relevance of PepT1 in the intestinal permeability and oral absorption of cefadroxil. Pharm Res 30:1017-25
Sun, Dongli; Wang, Yuqing; Tan, Fuqing et al. (2013) Functional and molecular expression of the proton-coupled oligopeptide transporters in spleen and macrophages from mouse and human. Mol Pharm 10:1409-16
Smith, David E; Clémençon, Benjamin; Hediger, Matthias A (2013) Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications. Mol Aspects Med 34:323-36

Showing the most recent 10 out of 84 publications