Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM036376-06
Application #
3290227
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1986-12-01
Project End
1993-03-31
Budget Start
1991-12-01
Budget End
1993-03-31
Support Year
6
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Louisiana State University Hsc Shreveport
Department
Type
Schools of Medicine
DUNS #
City
Shreveport
State
LA
Country
United States
Zip Code
71103
Ding, J; Magnotti, L J; Huang, Q et al. (2001) Hypoxia combined with Escherichia coli produces irreversible gut mucosal injury characterized by increased intestinal cytokine production and DNA degradation. Shock 16:189-95
Suzuki, Y; Deitch, E A; Mishima, S et al. (2000) Inducible nitric oxide synthase gene knockout mice have increased resistance to gut injury and bacterial translocation after an intestinal ischemia-reperfusion injury. Crit Care Med 28:3692-6
Suzuki, Y; Deitch, E A; Mishima, S et al. (2000) Endotoxin-induced mesenteric microvascular changes involve iNOS-derived nitric oxide: results from a study using iNOS knock out mice. Shock 13:397-403
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Xu, D Z; Lu, Q; Kubicka, R et al. (1999) The effect of hypoxia/reoxygenation on the cellular function of intestinal epithelial cells. J Trauma 46:280-5
Mishima, S; Xu, D; Deitch, E A (1999) Increase in endotoxin-induced mucosal permeability is related to increased nitric oxide synthase activity using the Ussing chamber. Crit Care Med 27:880-6
Grotz, M R; Deitch, E A; Ding, J et al. (1999) Intestinal cytokine response after gut ischemia: role of gut barrier failure. Ann Surg 229:478-86
Magnotti, L J; Upperman, J S; Xu, D Z et al. (1998) Gut-derived mesenteric lymph but not portal blood increases endothelial cell permeability and promotes lung injury after hemorrhagic shock. Ann Surg 228:518-27
Swank, G M; Lu, Q; Xu, D Z et al. (1998) Effect of acute-phase and heat-shock stress on apoptosis in intestinal epithelial cells (Caco-2). Crit Care Med 26:1213-7
Mishima, S; Xu, D; Lu, Q et al. (1998) The relationships among nitric oxide production, bacterial translocation, and intestinal injury after endotoxin challenge in vivo. J Trauma 44:175-82

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