Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM036415-06S1
Application #
3290344
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1986-08-01
Project End
1992-08-31
Budget Start
1992-06-15
Budget End
1992-07-31
Support Year
6
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Tufts University
Department
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02111
Woodbury, R L; Topping, T B; Diamond, D L et al. (2000) Complexes between protein export chaperone SecB and SecA. Evidence for separate sites on SecA providing binding energy and regulatory interactions. J Biol Chem 275:24191-8
Cook, H A; Kumamoto, C A (1999) Overproduction of SecA suppresses the export defect caused by a mutation in the gene encoding the Escherichia coli export chaperone secB. J Bacteriol 181:3010-7
Volkert, T L; Baleja, J D; Kumamoto, C A (1999) A highly mobile C-terminal tail of the Escherichia coli protein export chaperone SecB. Biochem Biophys Res Commun 264:949-54
Muren, E M; Suciu, D; Topping, T B et al. (1999) Mutational alterations in the homotetrameric chaperone SecB that implicate the structure as dimer of dimers. J Biol Chem 274:19397-402
Fekkes, P; de Wit, J G; van der Wolk, J P et al. (1998) Preprotein transfer to the Escherichia coli translocase requires the co-operative binding of SecB and the signal sequence to SecA. Mol Microbiol 29:1179-90
Francetic, O; Kumamoto, C A (1996) Escherichia coli SecB stimulates export without maintaining export competence of ribose-binding protein signal sequence mutants. J Bacteriol 178:5954-9
Kimsey, H H; Dagarag, M D; Kumamoto, C A (1995) Diverse effects of mutation on the activity of the Escherichia coli export chaperone SecB. J Biol Chem 270:22831-5
McFarland, L; Francetic, O; Kumamoto, C A (1993) A mutation of Escherichia coli SecA protein that partially compensates for the absence of SecB. J Bacteriol 175:2255-62
Francetic, O; Hanson, M P; Kumamoto, C A (1993) prlA suppression of defective export of maltose-binding protein in secB mutants of Escherichia coli. J Bacteriol 175:4036-44
Gannon, P M; Kumamoto, C A (1993) Mutations of the molecular chaperone protein SecB which alter the interaction between SecB and maltose-binding protein. J Biol Chem 268:1590-5

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