Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM037188-10
Application #
2178707
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1986-09-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Pharmacy
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Sun, Kefeng; Xu, Hao; Hilfinger, John L et al. (2018) Improved Protease-Targeting and Biopharmaceutical Properties of Novel Prodrugs of Ganciclovir. Mol Pharm 15:410-419
Incecayir, Tuba; Sun, Jing; Tsume, Yasuhiro et al. (2016) Carrier-Mediated Prodrug Uptake to Improve the Oral Bioavailability of Polar Drugs: An Application to an Oseltamivir Analogue. J Pharm Sci 105:925-934
Xu, Hao; Majmudar, Jaimeen D; Davda, Dahvid et al. (2015) Substrate-Competitive Activity-Based Profiling of Ester Prodrug Activating Enzymes. Mol Pharm 12:3399-407
Dahan, Arik; Wolk, Omri; Yang, Peihua et al. (2014) Dipeptidyl peptidase IV as a potential target for selective prodrug activation and chemotherapeutic action in cancers. Mol Pharm 11:4385-94
Walls, Zachary F; Gupta, Sheeba Varghese; Amidon, Gordon L et al. (2014) Synthesis and characterization of valyloxy methoxy luciferin for the detection of valacyclovirase and peptide transporter. Bioorg Med Chem Lett 24:4781-4783
Tsume, Yasuhiro; Incecayir, Tuba; Song, Xueqin et al. (2014) The development of orally administrable gemcitabine prodrugs with D-enantiomer amino acids: enhanced membrane permeability and enzymatic stability. Eur J Pharm Biopharm 86:514-23
Tsume, Yasuhiro; Mudie, Deanna M; Langguth, Peter et al. (2014) The Biopharmaceutics Classification System: subclasses for in vivo predictive dissolution (IPD) methodology and IVIVC. Eur J Pharm Sci 57:152-63
Gupta, Deepak; Varghese Gupta, Sheeba; Dahan, Arik et al. (2013) Increasing oral absorption of polar neuraminidase inhibitors: a prodrug transporter approach applied to oseltamivir analogue. Mol Pharm 10:512-22
Xu, Hao; Sabit, Hairat; Amidon, Gordon L et al. (2013) An improved synthesis of a fluorophosphonate-polyethylene glycol-biotin probe and its use against competitive substrates. Beilstein J Org Chem 9:89-96
Incecayir, Tuba; Tsume, Yasuhiro; Amidon, Gordon L (2013) Comparison of the permeability of metoprolol and labetalol in rat, mouse, and Caco-2 cells: use as a reference standard for BCS classification. Mol Pharm 10:958-66

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