Bicyclomycin (1) is a clinically useful antibiotic. Information gleaned from ongoing studies have provided the basis of our current notions concerning the mode of action of 1. Unfortunately, little is known concerning the drug activation process, the energetics of key steps, and the interaction of the antibiotic with the receptor site(s). In this proposal, a novel hypothesis for the mode of action of bicyclomycin has been advanced. An integrated approach has been outlined for the further understanding of how the drug and the receptor site function. Detailed experiments are also proposed to discern the effects provided by the biological medium in the drug activation and binding process. Knowledge of this general nature is expected to provide the molecular basis for subsequent research in this area, and allow future general drug design to proceed on a less empirical basis.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM037934-05
Application #
3293792
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1986-07-01
Project End
1994-06-30
Budget Start
1990-07-01
Budget End
1991-06-30
Support Year
5
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Houston
Department
Type
Schools of Arts and Sciences
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77204