Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM038097-09
Application #
2179135
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1987-04-01
Project End
1997-08-31
Budget Start
1996-01-01
Budget End
1997-08-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Biochemistry
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Slesina, Marco; Inman, Elisabeth M; Moore, Ann E et al. (2006) Movement of vault particles visualized by GFP-tagged major vault protein. Cell Tissue Res 324:403-10
Emre, Nil; Raval-Fernandes, Sujna; Kickhoefer, Valerie A et al. (2004) Analysis of MVP and VPARP promoters indicates a role for chromatin remodeling in the regulation of MVP. Biochim Biophys Acta 1678:33-46
Kickhoefer, Valerie A; Poderycki, Michael J; Chan, Edward K L et al. (2002) The La RNA-binding protein interacts with the vault RNA and is a vault-associated protein. J Biol Chem 277:41282-6
Kickhoefer, V A; Liu, Y; Kong, L B et al. (2001) The Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle. J Cell Biol 152:157-64
Stephen, A G; Raval-Fernandes, S; Huynh, T et al. (2001) Assembly of vault-like particles in insect cells expressing only the major vault protein. J Biol Chem 276:23217-20
Siva, A C; Raval-Fernandes, S; Stephen, A G et al. (2001) Up-regulation of vaults may be necessary but not sufficient for multidrug resistance. Int J Cancer 92:195-202
Schroeijers, A B; Siva, A C; Scheffer, G L et al. (2000) The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines. Cancer Res 60:1104-10
Kong, L B; Siva, A C; Kickhoefer, V A et al. (2000) RNA location and modeling of a WD40 repeat domain within the vault. RNA 6:890-900
Kickhoefer, V A; Siva, A C; Kedersha, N L et al. (1999) The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase. J Cell Biol 146:917-28
Kickhoefer, V A; Stephen, A G; Harrington, L et al. (1999) Vaults and telomerase share a common subunit, TEP1. J Biol Chem 274:32712-7

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