The long-term goal of this research project is to understand the molecular basis of cell motility, especially how actin filaments are assembled in vivo and how their assembly contributes to the control of cell shape and movement. The investigator's approach to this goal is to study how actin-binding proteins control actin assembly in vitro and in vivo. The investigator's continue their focus on capping protein, which binds to barbed ends of actin filaments. Capping protein (CP) is ubiquitous among eukaryotes. The investigator's work on specialized cell systems indicates that capping protein does function to control actin assembly and cell motility in vivo and this application proposes to extend those studies to more complex and interesting systems. In addition, study of CP has uncovered a novel form of cell motility, which they propose to investigate.
| Kim, Joanna; Cooper, John A (2018) Septins regulate junctional integrity of endothelial monolayers. Mol Biol Cell 29:1693-1703 |
| Yen, Matthew; Qi, Zongtai; Chen, Xuhua et al. (2018) Transposase mapping identifies the genomic targets of BAP1 in uveal melanoma. BMC Med Genomics 11:97 |
| Santiago-Tirado, Felipe H; Onken, Michael D; Cooper, John A et al. (2017) Trojan Horse Transit Contributes to Blood-Brain Barrier Crossing of a Eukaryotic Pathogen. MBio 8: |
| Zhou, Julie Y; Szasz, Taylor P; Stewart-Hutchinson, Phillip J et al. (2016) L-Plastin promotes podosome longevity and supports macrophage motility. Mol Immunol 78:79-88 |
| Wang, Xinxin; Galletta, Brian J; Cooper, John A et al. (2016) Actin-Regulator Feedback Interactions during Endocytosis. Biophys J 110:1430-43 |
| Xu, Xiaolu; Wang, Xinxin; Todd, Elizabeth M et al. (2016) Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration. J Immunol 197:1683-91 |
| Mooren, Olivia L; Kim, Joanna; Li, Jinmei et al. (2015) Role of N-WASP in Endothelial Monolayer Formation and Integrity. J Biol Chem 290:18796-805 |
| Mukherjee, Suranjana; Kim, Joanna; Mooren, Olivia L et al. (2015) Role of cortactin homolog HS1 in transendothelial migration of natural killer cells. PLoS One 10:e0118153 |
| Sherman, Marc S; Lorenz, Kim; Lanier, M Hunter et al. (2015) Cell-to-cell variability in the propensity to transcribe explains correlated fluctuations in gene expression. Cell Syst 1:315-325 |
| Onken, Michael D; Mooren, Olivia L; Mukherjee, Suranjana et al. (2014) Endothelial monolayers and transendothelial migration depend on mechanical properties of the substrate. Cytoskeleton (Hoboken) 71:695-706 |
Showing the most recent 10 out of 75 publications
