Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM038903-10
Application #
2179596
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1987-08-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215
Malhotra, Deepali; Fletcher, Anne L; Astarita, Jillian et al. (2012) Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks. Nat Immunol 13:499-510
Sharma, Chandan; Rabinovitz, Isaac; Hemler, Martin E (2012) Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin ?6?4. Cell Mol Life Sci 69:2233-44
Wang, Hong-Xing; Li, Qinglin; Sharma, Chandan et al. (2011) Tetraspanin protein contributions to cancer. Biochem Soc Trans 39:547-52
Wang, Hong-Xing; Kolesnikova, Tatiana V; Denison, Carilee et al. (2011) The C-terminal tail of tetraspanin protein CD9 contributes to its function and molecular organization. J Cell Sci 124:2702-10
Lafleur, Marc A; Xu, Daosong; Hemler, Martin E (2009) Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis. Mol Biol Cell 20:2030-40
Xu, Daosong; Sharma, Chandan; Hemler, Martin E (2009) Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein. FASEB J 23:3674-81
Kolesnikova, Tatiana V; Kazarov, Alexander R; Lemieux, Madeleine E et al. (2009) Glioblastoma inhibition by cell surface immunoglobulin protein EWI-2, in vitro and in vivo. Neoplasia 11:77-86, 4p following 86
Hemler, Martin E (2008) Targeting of tetraspanin proteins--potential benefits and strategies. Nat Rev Drug Discov 7:747-58
Fiorentino, Michelangelo; Zadra, Giorgia; Palescandolo, Emanuele et al. (2008) Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer. Lab Invest 88:1340-8
Sharma, Chandan; Yang, Xiuwei H; Hemler, Martin E (2008) DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151. Mol Biol Cell 19:3415-25

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