Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM040379-09
Application #
2180292
Study Section
Biochemistry Study Section (BIO)
Project Start
1988-07-01
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Biochemistry
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Kim, Jai-Hyun; Zhao, Yinsuo; Pan, Xuewen et al. (2009) The unfolded protein response is necessary but not sufficient to compensate for defects in disulfide isomerization. J Biol Chem 284:10400-8
Xiao, Ruoyu; Lundstrom-Ljung, Johanna; Holmgren, Arne et al. (2005) Catalysis of thiol/disulfide exchange. Glutaredoxin 1 and protein-disulfide isomerase use different mechanisms to enhance oxidase and reductase activities. J Biol Chem 280:21099-106
Wilkinson, Bonney; Xiao, Ruoyu; Gilbert, Hiram F (2005) A structural disulfide of yeast protein-disulfide isomerase destabilizes the active site disulfide of the N-terminal thioredoxin domain. J Biol Chem 280:11483-7
Xiao, Ruoyu; Wilkinson, Bonney; Solovyov, Anton et al. (2004) The contributions of protein disulfide isomerase and its homologues to oxidative protein folding in the yeast endoplasmic reticulum. J Biol Chem 279:49780-6
Solovyov, Anton; Xiao, Ruoyu; Gilbert, Hiram F (2004) Sulfhydryl oxidation, not disulfide isomerization, is the principal function of protein disulfide isomerase in yeast Saccharomyces cerevisiae. J Biol Chem 279:34095-100
Wilkinson, Bonney; Gilbert, Hiram F (2004) Protein disulfide isomerase. Biochim Biophys Acta 1699:35-44
Solovyov, Anton; Gilbert, Hiram F (2004) Zinc-dependent dimerization of the folding catalyst, protein disulfide isomerase. Protein Sci 13:1902-7
Schwaller, Melissa; Wilkinson, Bonney; Gilbert, Hiram F (2003) Reduction-reoxidation cycles contribute to catalysis of disulfide isomerization by protein-disulfide isomerase. J Biol Chem 278:7154-9
Primm, T P; Gilbert, H F (2001) Hormone binding by protein disulfide isomerase, a high capacity hormone reservoir of the endoplasmic reticulum. J Biol Chem 276:281-6
Xiao, R; Solovyov, A; Gilbert, H F et al. (2001) Combinations of protein-disulfide isomerase domains show that there is little correlation between isomerase activity and wild-type growth. J Biol Chem 276:27975-80

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