Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM040602-09
Application #
2180472
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1988-07-01
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Castañeda, Carol Ann; Wolfson, Noah A; Leng, Katherine R et al. (2017) HDAC8 substrate selectivity is determined by long- and short-range interactions leading to enhanced reactivity for full-length histone substrates compared with peptides. J Biol Chem 292:21568-21577
Niu, Shuai; Kim, Byung Chul; Fierke, Carol A et al. (2017) Ion Mobility-Mass Spectrometry Reveals Evidence of Specific Complex Formation between Human Histone Deacetylase 8 and Poly-r(C)-binding Protein 1. Int J Mass Spectrom 420:9-15
Lopez, Jeffrey E; Haynes, Sarah E; Majmudar, Jaimeen D et al. (2017) HDAC8 Substrates Identified by Genetically Encoded Active Site Photocrosslinking. J Am Chem Soc 139:16222-16227
Castaneda, Carol Ann; Lopez, Jeffrey E; Joseph, Caleb G et al. (2017) Active Site Metal Identity Alters Histone Deacetylase 8 Substrate Selectivity: A Potential Novel Regulatory Mechanism. Biochemistry 56:5663-5670
Temple, Kayla J; Wright, Elia N; Fierke, Carol A et al. (2016) Synthesis of Non-natural, Frame-Shifted Isoprenoid Diphosphate Analogues. Org Lett 18:6038-6041
Temple, Kayla J; Wright, Elia N; Fierke, Carol A et al. (2016) Exploration of GGTase-I substrate requirements. Part 2: Synthesis and biochemical analysis of novel saturated geranylgeranyl diphosphate analogs. Bioorg Med Chem Lett 26:3503-7
Bergom, Carmen; Hauser, Andrew D; Rymaszewski, Amy et al. (2016) The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases. J Biol Chem 291:6534-45
Gantt, Sister M Lucy; Decroos, Christophe; Lee, Matthew S et al. (2016) General Base-General Acid Catalysis in Human Histone Deacetylase 8. Biochemistry 55:820-32
López, Jeffrey E; Sullivan, Eric D; Fierke, Carol A (2016) Metal-dependent Deacetylases: Cancer and Epigenetic Regulators. ACS Chem Biol 11:706-16
Jennings, Benjamin C; Danowitz, Amy M; Wang, Yen-Chih et al. (2016) Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase. Bioorg Med Chem Lett 26:1333-6

Showing the most recent 10 out of 50 publications