Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM041605-19
Application #
2022285
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1977-08-01
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Nanda, Suman Yadav; Hoang, Thuy; Patel, Priya et al. (2014) Vinculin regulates assembly of talin: ?3 integrin complexes. J Cell Biochem 115:1206-16
Dumbauld, David W; Lee, Ted T; Singh, Ankur et al. (2013) How vinculin regulates force transmission. Proc Natl Acad Sci U S A 110:9788-93
Coyer, Sean R; Singh, Ankur; Dumbauld, David W et al. (2012) Nanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and cytoskeleton tension. J Cell Sci 125:5110-23
Peng, Xiao; Maiers, Jessica L; Choudhury, Dilshad et al. (2012) ?-Catenin uses a novel mechanism to activate vinculin. J Biol Chem 287:7728-37
Chen, Hui; Choudhury, Dilshad M; Craig, Susan W (2006) Coincidence of actin filaments and talin is required to activate vinculin. J Biol Chem 281:40389-98
Cohen, Daniel M; Kutscher, Brett; Chen, Hui et al. (2006) A conformational switch in vinculin drives formation and dynamics of a talin-vinculin complex at focal adhesions. J Biol Chem 281:16006-15
Chen, Hui; Cohen, Daniel M; Choudhury, Dilshad M et al. (2005) Spatial distribution and functional significance of activated vinculin in living cells. J Cell Biol 169:459-70
Cohen, Daniel M; Chen, Hui; Johnson, Robert P et al. (2005) Two distinct head-tail interfaces cooperate to suppress activation of vinculin by talin. J Biol Chem 280:17109-17
Johnson, R P; Craig, S W (2000) Actin activates a cryptic dimerization potential of the vinculin tail domain. J Biol Chem 275:95-105
Steimle, P A; Hoffert, J D; Adey, N B et al. (1999) Polyphosphoinositides inhibit the interaction of vinculin with actin filaments. J Biol Chem 274:18414-20

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