Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM041821-07
Application #
2181079
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1989-12-01
Project End
1997-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Smith 3rd, Amos B; Charnley, Adam K; Hirschmann, Ralph (2011) Pyrrolinone-based peptidomimetics. ""Let the enzyme or receptor be the judge"". Acc Chem Res 44:180-93
Hirschmann, Ralph F; Nicolaou, K C; Angeles, Angie R et al. (2009) The beta-D-glucose scaffold as a beta-turn mimetic. Acc Chem Res 42:1511-20
Foister, Shane; Taylor, Laurie L; Feng, Jin-Jye et al. (2006) Design and synthesis of potent cystine-free cyclic hexapeptide agonists at the human urotensin receptor. Org Lett 8:1799-802
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Neelamkavil, Santhosh; Arison, Byron; Birzin, Elizabeth et al. (2005) Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSST2 and hSST4. An unexpected effect of the chirality of Trp8 on NMR spectra in methanol. J Med Chem 48:4025-30
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Abrous, Leila; Jokiel, Patrick A; Friedrich, Sarah R et al. (2004) Novel chimeric scaffolds to extend the exploration of receptor space: hybrid beta-D-glucose-benzoheterodiazepine structures for broad screening. Effect of amide alkylation on the course of cyclization reactions. J Org Chem 69:280-302
Prasad, Vidya; Birzin, Elizabeth T; McVaugh, Cheryl T et al. (2003) Effects of heterocyclic aromatic substituents on binding affinities at two distinct sites of somatostatin receptors. Correlation with the electrostatic potential of the substituents. J Med Chem 46:1858-69
Smith 3rd, Amos B; Cantin, Louis-David; Pasternak, Alexander et al. (2003) Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors. J Med Chem 46:1831-44

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