Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM042071-08
Application #
2181209
Study Section
Immunobiology Study Section (IMB)
Project Start
1988-01-01
Project End
1999-11-30
Budget Start
1995-12-10
Budget End
1996-11-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Chicago
Department
Genetics
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Sevilla, L M; Richter, S S; Miller, J (2001) Intracellular transport of MHC class II and associated invariant chain in antigen presenting cells from AP-3-deficient mocha mice. Cell Immunol 210:143-53
Ashman, J B; Miller, J (1999) A role for the transmembrane domain in the trimerization of the MHC class II-associated invariant chain. J Immunol 163:2704-12
Fineschi, B; Arneson, L S; Naujokas, M F et al. (1995) Proteolysis of major histocompatibility complex class II-associated invariant chain is regulated by the alternatively spliced gene product, p41. Proc Natl Acad Sci U S A 92:10257-61
Swier, K; Miller, J (1995) Invariant chain-independent antigen presentation depends primarily upon the pool of newly synthesized MHC class II molecules. J Immunol 155:1851-61
Arneson, L S; Miller, J (1995) Efficient endosomal localization of major histocompatibility complex class II-invariant chain complexes requires multimerization of the invariant chain targeting sequence. J Cell Biol 129:1217-28
Naujokas, M F; Arneson, L S; Fineschi, B et al. (1995) Potent effects of low levels of MHC class II-associated invariant chain on CD4+ T cell development. Immunity 3:359-72
Swier, K; Miller, J (1995) Efficient internalization of MHC class II-invariant chain complexes is not sufficient for invariant chain proteolysis and class II antigen presentation. J Immunol 155:630-43
Anderson, M S; Swier, K; Arneson, L et al. (1993) Enhanced antigen presentation in the absence of the invariant chain endosomal localization signal. J Exp Med 178:1959-69
Go, C; Lancki, D W; Fitch, F W et al. (1993) Anergized T cell clones retain their cytolytic ability. J Immunol 150:367-76
Naujokas, M F; Morin, M; Anderson, M S et al. (1993) The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44. Cell 74:257-68

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