Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM042686-07
Application #
2181586
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1990-04-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Surgery
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Iwata, Akiko; de Claro, R Angelo; Morgan-Stevenson, Vicki L et al. (2011) Extracellular administration of BCL2 protein reduces apoptosis and improves survival in a murine model of sepsis. PLoS One 6:e14729
Iwata, Akiko; Morgan-Stevenson, Vicki; Schwartz, Barbara et al. (2010) Extracellular BCL2 proteins are danger-associated molecular patterns that reduce tissue damage in murine models of ischemia-reperfusion injury. PLoS One 5:e9103
Bannerman, Douglas D; Eiting, Kristine T; Winn, Robert K et al. (2004) FLICE-like inhibitory protein (FLIP) protects against apoptosis and suppresses NF-kappaB activation induced by bacterial lipopolysaccharide. Am J Pathol 165:1423-31
Iwata, Akiko; Stevenson, Vicki Morgan; Minard, Annie et al. (2003) Over-expression of Bcl-2 provides protection in septic mice by a trans effect. J Immunol 171:3136-41
Erwert, Ryan D; Eiting, Kristine T; Tupper, Joan C et al. (2003) Shiga toxin induces decreased expression of the anti-apoptotic protein Mcl-1 concomitant with the onset of endothelial apoptosis. Microb Pathog 35:87-93
Erwert, Ryan D; Winn, Robert K; Harlan, John M et al. (2002) Shiga-like toxin inhibition of FLICE-like inhibitory protein expression sensitizes endothelial cells to bacterial lipopolysaccharide-induced apoptosis. J Biol Chem 277:40567-74
Iwata, Akiko; Harlan, John M; Vedder, Nicholas B et al. (2002) The caspase inhibitor z-VAD is more effective than CD18 adhesion blockade in reducing muscle ischemia-reperfusion injury: implication for clinical trials. Blood 100:2077-80
Bannerman, Douglas D; Erwert, Ryan D; Winn, Robert K et al. (2002) TIRAP mediates endotoxin-induced NF-kappaB activation and apoptosis in endothelial cells. Biochem Biophys Res Commun 295:157-62
Bannerman, Douglas D; Tupper, Joan C; Erwert, Ryan D et al. (2002) Divergence of bacterial lipopolysaccharide pro-apoptotic signaling downstream of IRAK-1. J Biol Chem 277:8048-53
Bannerman, Douglas D; Tupper, Joan C; Kelly, James D et al. (2002) The Fas-associated death domain protein suppresses activation of NF-kappa B by LPS and IL-1 beta. J Clin Invest 109:419-25

Showing the most recent 10 out of 35 publications