Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM042833-08
Application #
2181689
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1989-07-01
Project End
1998-03-31
Budget Start
1996-07-01
Budget End
1998-03-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Boston College
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
045896339
City
Chestnut Hill
State
MA
Country
United States
Zip Code
02467
Cockrell, Gregory M; Kantrowitz, Evan R (2012) Metal ion involvement in the allosteric mechanism of Escherichia coli aspartate transcarbamoylase. Biochemistry 51:7128-37
Wang, Jie; Kantrowitz, Evan R (2006) Trapping the tetrahedral intermediate in the alkaline phosphatase reaction by substitution of the active site serine with threonine. Protein Sci 15:2395-401
Stec, Boguslaw; Holtz, Kathleen M; Wojciechowski, Cheryl L et al. (2005) Structure of the wild-type TEM-1 beta-lactamase at 1.55 A and the mutant enzyme Ser70Ala at 2.1 A suggest the mode of noncovalent catalysis for the mutant enzyme. Acta Crystallogr D Biol Crystallogr 61:1072-9
Wang, Jie; Stieglitz, Kimberly A; Kantrowitz, Evan R (2005) Metal specificity is correlated with two crucial active site residues in Escherichia coli alkaline phosphatase. Biochemistry 44:8378-86
Zappa, S; Boudrant, J; Kantrowitz, E R (2004) Pyrococcus abyssi alkaline phosphatase: the dimer is the active form. J Inorg Biochem 98:575-81
Boulanger Jr, Robert R; Kantrowitz, Evan R (2003) Characterization of a monomeric Escherichia coli alkaline phosphatase formed upon a single amino acid substitution. J Biol Chem 278:23497-501
Wojciechowski, Cheryl L; Kantrowitz, Evan R (2003) Glutamic acid residues as metal ligands in the active site of Escherichia coli alkaline phosphatase. Biochim Biophys Acta 1649:68-73
Wojciechowski, Cheryl L; Cardia, James P; Kantrowitz, Evan R (2002) Alkaline phosphatase from the hyperthermophilic bacterium T. maritima requires cobalt for activity. Protein Sci 11:903-11
Wojciechowski, Cheryl L; Kantrowitz, Evan R (2002) Altering of the metal specificity of Escherichia coli alkaline phosphatase. J Biol Chem 277:50476-81
Hehir, M J; Murphy, J E; Kantrowitz, E R (2000) Characterization of heterodimeric alkaline phosphatases from Escherichia coli: an investigation of intragenic complementation. J Mol Biol 304:645-56

Showing the most recent 10 out of 30 publications